Evaluation of the synergistic effect of chitosan metal ions (Cu/Co) in combination with antibiotics to counteract the effects on antibiotic resistant bacteria.

The effectiveness of antibiotics that save millions of lives is in danger due to the increasing rise of resistant bacteria around the world. We proposed chitosan-copper ions (CSNP-Cu) and chitosan-cobalt ion nanoparticles (CSNP-Co) as biodegradable nanoparticles loaded with metal ions synthesized an ionic gelation method for treatment of antibiotic resistant bacteria. The nanoparticles were characterized using TEM, FT-IR, zeta potential and ICP-OES.