Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome.

Background And Aim: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS).

Materials And Methods: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI.

Assessment of the natural killer cell, IFN- and IL-10 blood levels in children with attention-deficit/hyperactivity disorder.

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, affects millions of youngsters and typically persists into adulthood. The pathophysiology of ADHD may be due to an impaired immune response, common genetics, and environmental linkages, as all have been suggested as potential underlying mechanisms for ADHD. During systemic inflammation, natural killer (NK) cells can produce pro-inflammatory cytokines like interferon (IFN- ) and anti-inflammatory cytokines like interleukin (IL-10); this demonstrates the importance of both of their roles as regulators to counteract inflammation and prevent immune-mediated host damage.

Serum metabolomic profiles and semaphorin-3A as biomarkers of diabetic retinopathy progression.

Diabetic retinopathy (DR) is a typical microvascular complication of diabetes mellitus (DM) and it remains one of the leading causes of vision loss worldwide. Studies postulated that a distinct metabolic signature of DR exists and can be resolved from that of diabetes alone. Serum Semaphorin3A (Sema3A) levels have also been found to be correlated with the phenotypes of diabetic retinopathy.

Maternal serum perlecan and ischemia modified albumin levels as biomarkers of preeclampsia severity.

Preeclampsia (PE) is a pregnancy disorder characterized by hypertension and end-organ damage. Reliable biochemical markers for diagnosis and prediction of PE severity can improve maternal health, and several of these markers have been suggested till now. The goal of our study was to evaluate maternal serum levels of Perlecan and Ischemia modified albumin (IMA) in PE patients, and to investigate their relationship with the severity.