Publications by authors named "Mona F Mansour"
Background: Injection of adipose-derived stem cells (ADSCs) into the injured tunica albuginea (TA) may prevent fibrosis, restore the balance between pro- and antifibrotic pathways, and potentially mitigate erectile dysfunction caused by abnormal TA healing.
Aim: To assess the potential role of ADSC injection on structural, ultrastructural, functional, and molecular changes in surgically induced trauma of the rat's TA.
Methods: Forty adult male albino Wistar rats were divided into 5 groups of 8 rats each: group 1, sham; group 2, injury to TA without treatment; group 3, injury to TA and suture repair; group 4, injury to TA and injection of ADSCs without suture repair; group 5, injury to TA followed by injection of ADSCs and suture repair.
Chronic kidney disease (CKD) is a priority health problem affecting 36% of Egyptians. Adipose-derived mesenchymal stem cells (ADMSCs) have multidifferentiation capacity and the ability to restore several types of cells including damaged renal cells. Granulocyte colony-stimulating factor (G-CSF) is known to mobilize hematopoietic stem cells from bone marrow to the peripheral circulation.
View Article and Find Full Text PDFMethotrexate (MTX) is a folic acid antagonist, widely used as a chemotherapeutic and immunosuppressive drug, but it is toxic to reproductive systems. In recent years, the era of stem cell applications becomes a promising point as a possible therapeutic agent in male infertility. This study is aimed at evaluating the therapeutic effects of stem cells at histological, molecular, biochemical, and functional levels in a methotrexate-induced testicular damage model.
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- - The study investigates the relationship between two specific single nucleotide polymorphisms (SNPs) in the AIRE gene (rs760426 and rs2075876) and the risk of developing rheumatoid arthritis (RA) in a population from the Suez Canal Zone, comprising 100 RA patients and 100 healthy controls.
- - Findings showed that the rs760426 polymorphism significantly increased the A/G genotype frequency in RA patients compared to controls and was linked to longer RA duration and higher anti-cyclic citrullinated peptide antibody levels. Conversely, rs2075876 was associated with a higher frequency of the A/A genotype in RA patients and correlated with higher body mass index and rheumatoid factor positivity.
- - Overall, the study concludes
End-stage liver disease is a worldwide cause of morbidity and mortality, which is associated with a considerable economic burden. As the disease progresses, fibrosis will replace the hepatic architecture and compromise liver functions. The regenerative approach for the injured liver can provide a hope for these patients; however, it is still facing many challenges.
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