Publications by authors named "Mona A Yehia"

Article Synopsis
  • Triple negative breast cancer (TNBC) is a highly aggressive cancer subtype with poor survival rates, prompting interest in less toxic metal-based therapies like copper complexes.
  • This study investigates the effects of copper(I) nicotinate (CNC) on TNBC cell lines, focusing on its influence on the Notch1 signaling pathway and its potential to induce apoptotic cell death alongside the traditional drug doxorubicin (Doxo).
  • While CNC demonstrated promising anti-cancer activities by modulating the Notch1 pathway differently depending on the cell type and dosage, these factors must be carefully considered for effective treatment strategies.
View Article and Find Full Text PDF

The present study was designated to assess oxidative damage and its effect on germ cell apoptosis in testes of streptozotocin (STZ)-induced diabetic rats. The role of antioxidant supplementation with a mixture of vitamins E and C and alpha lipoic acid for protection against such damage was also evaluated. Forty-five adult male rats were randomly divided into three groups: group I, control, non-diabetic rats; group II, STZ-induced, untreated diabetic rats; group III, STZ-induced diabetic rats supplemented with a mixture of vitamins E and C and alpha lipoic acid.

View Article and Find Full Text PDF

Diazinon is a widely used pesticide in agriculture. So, the current work aimed to investigate the effects of diazinon exposure on some physiological and biochemical parameters, as well as, histopathological changes and histochemical acetyl-cholinesterase activity (AChE). The red Baladi rabbits were dipped into water (Control Group), diazinon at low concentrations of 0.

View Article and Find Full Text PDF

Rats were divided into two experimental groups received single or split doses of PZQ, and two control groups one infected untreated and the other normal healthy rats. The effect of infection on rat growth, on jejunal and duodenal architecture were studied histopathologically after H&E staining. The jejunal ultrastructure was examined by SEM and TEM.

View Article and Find Full Text PDF