Continuous Wavelet Transform as a Signal Processing Technique for Spectrofluorimetric Analysis of Rosuvastatin and Losartan: Greenness and Blueness Assessment.

In this study, the application of continuous wavelet transform as a signal processing technique for the spectrofluorimetric determination of rosuvastatin and losartan is investigated. Both rosuvastatin and losartan exhibited native spectrofluorometric signals with severe overlapping peaks, making their simultaneous determination challenging. To address this issue, rbio 2.

A simple eco-friendly spectrofluorimetric resolution approach for the simultaneous determination of Naproxen and Domperidone in pharmaceutical formulation and human plasma; assessment of method greenness.

Designing new verified methods for the determination of pharmaceutical compounds in their specified formulation without prior separation and with high sensitivity taking in consideration analytical performance and simplicity has become a major concern of pharmaceutical quality control units. In the present work, a new simple and eco-friendly spectrofluorimetric method was developed and validated for the determination of Naproxen (NAP) and Domperidone (DOM) in their binary mixture, pharmaceutical formulation in addition to human plasma without prior separation. The proposed method is based on measuring the second derivative fluorescence intensity for NAP at 345 nm and for DOM at 292 after excitation at 235 nm without any interference from each other.

Novel analytical method based on chemometric models applied to UV-Vis spectrophotometric data for simultaneous determination of Etoricoxib and Paracetamol in presence of Paracetamol impurities.

The multivariate models that are used for spectral data analysis have many beneficial applications, and one of the important applications is the analysis of drugs and their impurities. Three Chemometrically-assisted spectrophotometric models have been proposed and validated. The proposed models are Partial Least Squares (PLS), Artificial Neural Networks (ANN), and Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS).

Validated HPLC-PDA methodology utilized for simultaneous determination of Etoricoxib and Paracetamol in the presence of Paracetamol toxic impurities.

Etoricoxib (ETO), Paracetamol (PCM), and two toxic impurities for Paracetamol impurity K (4-aminophenol (PAP)) and impurity E (para-hydroxy acetophenone (PHA)) were separated using a simple and selective HPLC method that was tested for the first time. PCM is a commonly used analgesic and antipyretic medication that has recently been incorporated into COVID-19 supportive treatment. Pharmaceuticals containing PCM in combination with other analgesic-antipyretic drugs like ETO help to improve patient compliance.

Experimentally designed electrochemical sensor for therapeutic drug monitoring of Ondansetron co-administered with chemotherapeutic drugs.

The experimental design extracts valuable information about the main effects and interactions from the least number of experiments. The current work constructs a solid-state sensor for selective assay of Ondansetron (OND) in pharmaceutical dosage form and plasma samples. During optimization, the Design Expert statistical package constructed a custom design of 15 sensors with different recipes.

Highly selective heteroaromatic sulfur containing polyamides for Hg environmental remediation.

Environmental remediation concerns about pollution and contamination removal from environmental media, such as soil, air, or surface water. Enormous efforts have been applied in metal removal from surface water. In this study, four novel heteroaromatic sulfur-containing polyamides carry both types of aliphatic and aromatic species in their polymer backbones as selective adsorbents for Hg metal ion from aqueous solution have been synthesized in considerable amounts.

Design, synthesis and cytotoxic activity of water-soluble quinones with dibromo--benzoquinone cores and amino oligo(ethylene glycol) side chains against MCF-7 breast cancer cells.

A series of novel quinones was synthesized by reacting tetrabromo--benzoquinone with amino oligo(ethylene glycol) dendrons of generation numbers = 0-2. According to the performed shake-flask experiments, their aqueous solubility ( = 18 mg l-1.6 g ml) and partition coefficients (log  = 2.

Solvatochromism of dye-labeled dendronized polymers of generation numbers 1-4: comparison to dendrimers.

Two series of dendronized polymers (DPs) of generations = 1-4 with different levels of dendritic substitution (low and high) and a solvatochromic probe at = 1 level are used to study their swelling behavior in a collection of solvents largely differing in polarity as indicated by the Kamlet-Taft parameters. This is done by measuring the UV-Vis spectra of all samples in all solvents and determining the longest wavelength absorptions (). The values fall into a range defined by the extreme situations, when the solvatochromic probe is either fully surrounded by solvent or completely shielded against it.

Antibiotic resistance and polymorphism in the quinolone resistance-determining region of Campylobacter spp. isolated from 1-day-old ducklings.

Thirty-three isolates of Campylobacter coli and three isolates of Campylobacter jejuni were recovered from 150 1-day-old ducklings. All isolates were sensitive to chloramphenicol and amikacin, but resistant to sulfamethoxazole-trimethoprim (SXT) by the disc diffusion method. Most isolates were susceptible to tetracycline and erythromycin, but resistant to ofloxacin and ciprofloxacin.

Thermoresponsive dendrimers based on oligoethylene glycols: design, synthesis and cytotoxic activity against MCF-7 breast cancer cells.

Three interesting thermoresponsive branched oligoethylene glycol dendrimers based on tetrabromohydroquinone were efficiently synthesized from tetrabromohydroquinone and three different oligoethylene glycol derivatives. By visual inspection, all these dendrimers are water-soluble at room temperature. The thermoresponsive behaviors were investigated by using UV/vis turbidity measurement at different temperatures for 0.