Publications by authors named "Momoko Matsuoka"
Article Synopsis
- The study focuses on understanding the function of the PmrAB two-component system (TCS) in resistance to colistin, a last-resort antibiotic, in extensively drug-resistant (XDR) Gram-negative bacteria.
- Researchers conducted transcriptome analysis to identify the regulatory genes controlled by PmrAB, revealing its responsiveness to environmental factors like pH and metal ions (Fe, Zn, Al).
- The findings highlight PmrAB's role in both environmental adaptation and the development of antibiotic resistance by modifying lipooligosaccharide (LOS) to mitigate toxicity and enhance resistance to colistin and polymyxin B.
