Activation of the DNA damage checkpoint perturbs asymmetric localization of Kar9 to spindle pole bodies in Saccharomyces cerevisiae.

During cell cycle progression in Saccharomyces cerevisiae, spindle pole bodies (SPBs) are duplicated during the G1/S-phase transition. SPBs are crucial for the organization of both the spindle and astral microtubules, and their orientation defines the direction of nuclear division. In this process, an old SPB, which serves as the template SPB during the duplication process, is oriented toward the bud side.

PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons.

PC3 is a member of the BTG/Tob family of antiproliferative genes. Here, we report the results of an analysis of PC3 protein expression in spiral ganglion neurons of the rat cochlea at embryonic days 16 (E16) and 20 (E20), and postnatal days 4 (P4) and 7 (P7). PC3 expression was observed in the cytoplasm of ganglion neurons at E16 and E20, and this protein had translocated to the nucleus by P4.

Preliminary experience with beta-tricalcium phosphate for use in mastoid cavity obliteration after mastoidectomy.

Objective: To examine the efficacy and safety of mastoid cavity obliteration using highly purified beta-tricalcium phosphate (beta-TCP) after mastoidectomy in middle ear surgery.

Patients: Thirteen patients with cholesteatoma invading the mastoid cavity or showing severe pathologic changes in the mastoid cavity.

Intervention: Twelve patients underwent mastoid obliteration with highly purified beta-TCP during the first- and/or second-stage operation of a 2-stage canal-up operation: 5 patients during the first and second stages, and 7 patients during the second stage only.

A case of migratory fish bone in the thyroid gland.

Fish-bone foreign bodies represent a common condition readily identified in the pharynx. We encountered a case of fish bone in the thyroid gland. Only three other such cases have been reported in the English-language literature.