Publications by authors named "Momo Arai"
Minimal residual disease testing for classical Hodgkin lymphoma: A comprehensive review.
Crit Rev Oncol Hematol
December 2024
Classical Hodgkin lymphoma (cHL) is a common lymphoma that affects young patients. Fortunately, the disease is highly curable as it is susceptible to the currently available treatment modalities. Disease monitoring with Positron Emission Tomography and Computed Tomography (PET/ CT) is an integral part of managing these patients.
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- * Early detection is crucial but challenging because symptoms can be minimal or non-specific, and traditional screening methods like imaging and biopsy have limitations in accuracy, cost, and invasiveness.
- * Innovative biosensors are emerging as a rapid, cost-effective, and less invasive alternative for detecting HCC by identifying various biomarkers, showing promise for improved early diagnosis compared to conventional methods.
Hepatocellular carcinoma (HCC) is currently one of the most prevalent cancers worldwide. Associated risk factors include, but are not limited to, cirrhosis and underlying liver diseases, including chronic hepatitis B or C infections, excessive alcohol consumption, nonalcoholic fatty liver disease (NAFLD), and exposure to chemical carcinogens. It is crucial to detect this disease early on before it metastasizes to adjoining parts of the body, worsening the prognosis.
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- Gene therapies like TNNT2-4Fpolycistronic-NIL have shown promise in treating subacute ischaemic heart failure (IHF) by inducing cardiomyocyte (CM) cell cycle re-entry but need testing in chronic IHF settings for broader clinical relevance.
- In the study, rats with induced chronic IHF were treated with TNNT2-4Fpolycistronic-NIL, which led to reduced scar size and improved left ventricular function over four months, though it didn't prevent LV dilation associated with chronic IHF.
- The findings suggest that this gene therapy effectively promotes CM regeneration in chronic IHF, highlighting potential new treatment avenues for this widespread condition.