Evaluating shear in perfusion rotary lobe pump using nanoparticle aggregates and computational fluid dynamics.

Perfusion cell culture technology has gained a lot of interest in recent years in the biopharmaceutical industry. One common application is N-1 perfusion which is used to intensify fed batch production processes and increase facility output. Upon running our perfusion process for the first time at manufacturing scale, unexpected cell damage was observed.

Using CFD simulations and statistical analysis to correlate oxygen mass transfer coefficient to both geometrical parameters and operating conditions in a stirred-tank bioreactor.

Optimization of a bioreactor design can be an especially challenging process. For instance, testing different bioreactor vessel geometries and different impeller and sparger types, locations, and dimensions can lead to an exceedingly large number of configurations and necessary experiments. Computational fluid dynamics (CFD), therefore, has been widely used to model multiphase flow in stirred-tank bioreactors to minimize the number of optimization experiments.

A new technique to improve the mechanical and biological performance of ultra high molecular weight polyethylene using a nylon coating.

A new patent pending technique is proposed in this study to improve the mechanical and biological performance of ultra high molecular weight polyethylene (UHMWPE), i.e., to uniformly coat nylon onto the UHMWPE fiber (Firouzi et al.