Publications by authors named "Molood Safarirad"
Objectives: Immunoglobulin A deficiency (IgAD) is a common disease with an unknown genetic defect, characterized by the decreased or absent IgA with other isotypes normal, normal subclasses, and specific antibodies. Patients with this disorder represent a spectrum of clinical manifestations including infections, autoimmune disorders, malignancy, and allergic diseases. The current study aimed to evaluate their prevalence and categorized them.
View Article and Find Full Text PDFBackground: Combined immune deficiencies (CIDs) with associated or syndromic features are a highly heterogeneous subgroup of inherited immune disorders. These patients represent specific clinical complications with an increased risk of autoimmune conditions.
Methods: We analyzed data of monogenic patients with syndromic CIDs adopted from the Iranian inborn errors of immunity registry up to January 2022.
Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection.
Allergol Immunopathol (Madr)
November 2021
Background: The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people around the world. This zoonotic-enveloped virus is primarily transmitted through inhalation. Infected people are commonly asymptomatic or manifest mild symptoms, including fever, cough, diarrhea, and fatigue.
View Article and Find Full Text PDFThe First Case Report of Kabuki Syndrome from the National Iranian Registry of Primary Immunodeficiencies.
Endocr Metab Immune Disord Drug Targets
April 2022
Article Synopsis
- - Kabuki syndrome is a rare condition marked by intellectual disability and developmental delays, with specific facial features like long eyelid openings and prominent finger pads, primarily caused by changes in KMT2D and KDM6A genes.
- - The first reported case of Kabuki syndrome in Iran showed an individual with an IQ of 79 and distinct features such as prominent ears, episodes of pneumonia, and persistent fingertip pads.
- - Genetic testing, specifically whole-exome sequencing, identified two significant mutations in the KMT2D gene, confirming the diagnosis of Kabuki syndrome based on these genetic and clinical characteristics.
Article Synopsis
- COVID-19 is less likely to cause life-threatening conditions in individuals under 50, but its effects on pediatric patients with primary immunodeficiency (PID) are unclear.
- A study shows that PID patients experience a 1.23 times higher incidence of infections but have a 10 times higher mortality rate, particularly among those with combined immunodeficiency and immune dysregulation.
- To improve survival rates in these PID patients, more treatment options like hematopoietic stem cell transplantation and immunomodulatory agents need to be explored.