Publications by authors named "Molly Sarah George"
J Immunother Cancer
June 2023
Article Synopsis
- The study focuses on a new immunotherapy approach called T4, designed to treat locally advanced/recurrent head and neck squamous cell carcinoma (HNSCC) by targeting upregulated ErbB proteins in tumor cells.
- This phase 1 trial involved injecting engineered CAR T-cells directly into tumors, with doses provided in escalating amounts, and showcased that these T-cells could be successfully manufactured from patient blood without toxic effects.
- In terms of results, the treatment showed manageable side effects (mostly mild) and demonstrated localized persistence of T-cells in the tumor site, however, it did not halt rapid tumor progression in patients.
