Utilization outcomes of direct oral anticoagulants in Medicare patients.

Objective: To compare the adherence, persistence, discontinuation and switching rates of direct oral anticoagulants (DOACs) for Medicare patients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE).

Methods: This was retrospective observational cohort study design. Medicare Part D claims files were used for the study duration (2015-2018).

QTc prolongation risk among patients receiving oral targeted antineoplastic medications: A real-world community-based oncology analysis.

Introduction: Thirty oral targeted antineoplastic agents are associated with prolongation of the QT interval. However, limited data exists regarding QTc prolongation and associated risk factors in the ambulatory oncology setting.

Methods: This retrospective study was completed to describe QTc prolongation incidence among patients receiving oral targeted tyrosine kinase inhibitors (TKI) and identify potential risk factors in the ambulatory community-based oncology clinic.

Impact of comparative effectiveness research on Medicare coverage of direct oral anticoagulants.

To evaluate the association of comparative effectiveness research with Medicare coverage of direct oral anticoagulants. A literature review for direct oral anticoagulants was conducted from 2011 to 2017. Monthly prescription drug plan and formulary files (n = 28) were used to conduct change-point analysis and assess each outcome variable.

Targeting EGFR Exon 20 Insertion Mutation in Non-small cell Lung Cancer: Amivantamab and Mobocertinib.

Objective: To evaluate clinical data regarding the use of amivantamab and mobocertinib for epidermal growth factor receptor (EGFR) exon 20 insertion mutation non-small cell lung cancer (NSCLC) and assess their potential impact on the care of patients.

Data Sources: A comprehensive literature search of PubMed and Clinicaltrials.gov was conducted using the terms , , , , ,

Study Selection And Data Extraction: Relevant English-language clinical trials were evaluated.

Verification of the Spotted-Tail Quoll, Dasyurus maculatus, as a Definitive Host for the Pentastomid Linguatula sp. in Australia.

Purpose: Specimens of a pentastomid, identified as a nymphal Linguatula serrata, have previously been reported from the nasal cavity of the endangered Australian marsupial, the spotted-tail quoll, Dasyurus maculatus. These specimens were made available for morphological and molecular characterisation to confirm their species identity.

Methods: Specimens were examined by light microscopy.

The feasibility and validity of a wearable sensor system to assess the stability of high-functioning lower-limb prosthesis users.

Introduction: Lower-limb prosthesis users (LLPUs) experience increased fall risk due to gait and balance impairments. Clinical outcome measures are useful for measuring balance impairment and fall risk screening but suffer from limited resolution and ceiling effects. Recent advances in wearable sensors that can measure different components of gait stability may address these limitations.

Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.

Habitual aerobic exercise is associated with enhanced endothelium-dependent dilatation (EDD) in older humans, possibly by increasing nitric oxide bioavailability and reducing oxidative stress. However, the mechanisms involved are incompletely understood. EDD was measured in young (6-8 months) and old (29-32 months) cage control and voluntary wheel running (VR) B6D2F1 mice.