Publications by authors named "Molly Morrissey"
Article Synopsis
- - TLR9 agonists, particularly nelitolimod, enhance the immune response against liver tumors by promoting the killing of micro-organisms and cancer cells, although their effectiveness is limited by specific immune cell behaviors and drug delivery challenges.
- - A new delivery method called pressure-enabled drug delivery (PEDD) improves the targeting of TLR9 agonists to tumors, leading to increased depletion of suppressive immune cells (MDSCs) and overall immune stimulation, especially when combined with checkpoint inhibitors.
- - In experiments with mice, the system showed promising results when nelitolimod was given directly to the tumor alongside either systemic or subcutaneous administration of immune checkpoint inhibitors, resulting in notable changes in immune cell populations within the tumors.
: Risk factors for young adults with mTBI are not well understood. Improved understanding of age and sex as risk factors for impaired six-month outcomes in young adults is needed. : Young adult mTBI subjects aged 18-39 years (18-29y; 30-39y) with six-month outcomes were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study.
View Article and Find Full Text PDFIntroduction: Mild traumatic brain injury (MTBI) can cause persistent functional deficits and healthcare burden. Understanding the association between intracranial contusions and outcome may aid in MTBI treatment and prognosis.
Methods: MTBI patients with Glasgow Coma Scale 13-15 and 6-month outcomes [Glasgow Outcome Scale-Extended (GOSE)], without polytrauma from the prospective TRACK-TBI Pilot study were analyzed.
Background: Preinjury employment status may contribute to disparity, injury risk, and recovery patterns following mild traumatic brain injury (MTBI).
Objective: To characterize associations between preinjury unemployment, prior comorbidities, and outcomes following MTBI.
Methods: MTBI patients from TRACK-TBI Pilot with complete six-month outcomes were extracted.
This review of the literature on traumatic brain injury (TBI) in older adults focuses on incident TBI sustained in older adulthood ("geriatric TBI") rather than on the separate, but related, topic of older adults with a history of earlier-life TBI. We describe the epidemiology of geriatric TBI, the impact of comorbidities and pre-injury function on TBI risk and outcomes, diagnostic testing, management issues, outcomes, and critical directions for future research. The highest incidence of TBI-related emergency department visits, hospitalizations, and deaths occur in older adults.
View Article and Find Full Text PDF