Salvage cryotherapy in patients undergoing endoscopic eradication therapy for complicated Barrett's esophagus.

 Some patients with dysplastic Barrett's esophagus (BE) experience suboptimal response to radiofrequency ablation (RFA), endoscopic mucosal resection (EMR), or the combination. Cryotherapy has been used as salvage therapy in these patients, but outcomes data are limited. We aimed to assess clinical outcomes among a large cohort of patients with dysplastic BE whose condition had failed to respond to RFA and/or EMR.

Identification of high resource utilizing patients on internal medicine hospital services.

In order to provide high quality, cost-efficient care, it is critical to understand drivers of the cost of care. Therefore, we sought to identify clinical variables associated with high utilization (cost) in patients admitted to medical services and to develop a robust model to identify high utilization patients. In this case-control analysis, cases were identified as the 200 most costly patients admitted to internal medicine/internal medicine subspecialty services using our institution's computerized clinical data warehouse over a 7-month time period (November 1, 2012-May 31, 2013).

The characterization of a base-width neutral step as the first step for balance recovery in moderate Parkinson's disease.

Purpose: The purpose of this study is to characterize the base-width neutral step (BNS) as the first step in a compensatory step response in persons with moderate Parkinson's disease (PD), and its effect on balance recovery.

Materials And Methods: Ten PD and 10 healthy controls (HCs) responded to a posterior waist pull. A BNS was defined if the first step was less than 50 mm.

The effect of moderate Parkinson's disease on compensatory backwards stepping.

Postural instability is a major unmet need in the treatment of Parkinson's disease (PD) and its progression is not well understood. This study examined compensatory stepping taken in response to a backwards waist pull in participants with moderate PD (H&Y III) compared to age-range matched healthy controls (HC). The first step in the response was quantified in terms of strategy, temporal, kinematic, and center of pressure (COP) parameters previously observed to be significantly different in mild PD (H&Y II) compared to HC.

Postural sway in patients with mild to moderate Parkinson's disease.

Clinical assessment of postural instability in persons with Parkinson's disease (PD) is done with the retropulsive pull test, but since this test does not assess the underlying causes of postural instability, there is a need for additional assessment tools. The aim of this study was to identify postural sway parameters for use in a multifactorial approach to quantify postural instability. Nineteen adults diagnosed with idiopathic PD, 14 healthy age-matched controls (EH), and 10 healthy young adults (YH) completed the study.

Early biomechanical markers of postural instability in Parkinson's disease.

Current clinical assessments do not adequately detect the onset of postural instability in the early stages of Parkinson's disease (PD). The aim of this study was to identify biomechanical variables that are sensitive to the effects of early Parkinson's disease on the ability to recovery from a balance disturbance. Ten adults diagnosed with idiopathic PD and no clinically detectable postural instability, and ten healthy age-range matched controls (HC) completed the study.