Publications by authors named "Molly Broache"
Article Synopsis
- A study evaluated adherence to CDC testing guidelines for vaginitis among insured women in the US, focusing on testing frequency and co-testing rates for vaginitis and STIs.
- Approximately 48% of 1.36 million women were diagnosed with vaginitis, but only 34% were also screened for Chlamydia and Gonorrhea.
- Results indicated that women tested with nucleic acid amplification for vaginitis had higher rates of co-testing for STIs, suggesting that molecular diagnostics could enhance women's health care access.
Objective: To compare the performance of vaginitis diagnosis based on clinical assessment to molecular detection of organisms associated with bacterial vaginosis, vulvovaginal candidiasis, and Trichomonas vaginalis using a vaginal panel assay.
Methods: This cross-sectional diagnostic accuracy study included 489 enrolled participants from five collection sites where those with vaginitis symptoms had a vaginal assay swab collected during their visit and a clinical diagnosis made. The swab was later sent to a separate testing site to perform the vaginal panel assay.
Histone deacetylase 3 (HDAC3) is an epigenome-modifying enzyme that is required for normal mouse development and tissue-specific functions. In vitro, HDAC3 protein itself has minimal enzyme activity but gains its histone-deacetylation function from stable association with the conserved deacetylase-activating domain (DAD) contained in nuclear receptor co-repressors NCOR1 and SMRT. Here we show that HDAC3 enzyme activity is undetectable in mice bearing point mutations in the DAD of both NCOR1 and SMRT (NS-DADm), despite having normal levels of HDAC3 protein.
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