Clinical Manifestations.

Background: Objective and sensitive measures of everyday function are needed for accurate clinical diagnosis and evaluation of outcomes in clinical trials for dementia. However, most objective everyday function measures are difficult to administer and have not been validated against biomarkers of Alzheimer's disease (AD) neuropathology. This study evaluated the neuroimaging correlates of a highly sensitive, ecologically valid, and easily implementable performance-based test of function called the Virtual Kitchen Challenge (VKC).

Clinical Manifestations.

Background: Mild functional difficulties begin in mild cognitive impairment (MCI) and precede functional disability, but people with MCI generally perform at ceiling on performance-based tests of everyday function. This study examined whether inefficient reaching, touching, and extra movements (i.e.

Clinical Manifestations.

Background: Greater physical activity (PA) is associated with better cognitive and vascular health, but accurate assessment of PA is challenging. Self-report questionnaires of PA may be compared against objective measures from smartwatch sensors; the correspondence between measures may be influenced by a variety of factors such as cognition or age. The focus of this study was to identify baseline participant characteristics (vascular risk, cognition) that influence the association between self-reported PA and PA measured with a Garmin Vivosmart 4 smartwatch in a racially diverse sample of older adults.

Clinical Manifestations.

Background: The Goal-Control Model posits that episodic memory impairment leads to premature decay of everyday task goals, which contributes to task omissions (failure to accomplish task steps) in those with moderate to severe impairment. Although task omissions are not observed in those with mild episodic memory (mildEM) impairment, it has yet to be investigated if goal decay is reflected by subtle errors during task completion. We hypothesized that goal decay in mildEM impairment is reflected by imprecision in task performance at the end of everyday tasks.

Clinical Manifestations.

Background: The impact of depressive symptoms on everyday function in older adults remains poorly understood. Depression may decrease motivation, impair cognition, and/or bias self-reports of functional ability. The present study examined relations between depressive symptoms and everyday function as measured by self-report, informant-report, and an objective performance-based measure which evaluates functional/cognitive capacity but requires only minimal motivation.

The frequency of self-reported memory failures is influenced by everyday context across the lifespan: Implications for neuropsychology research and clinical practice.

To investigate the influence of contextual factors on self-reports of cognitive abilities, this study investigated whether the frequency of self-reported memory failures was affected by level of daily busyness (Busyness) and daily routines (Routine) and whether age moderated these relations. The influence of the COVID-19 pandemic on self-reported memory failures also was explored. 902 community-dwelling participants ( age= 56.