Publications by authors named "Molly A Guscott"
Interleukin (IL)-33 is released following tissue damage, causing airway inflammation and remodelling via reduced IL-33 (IL-33)/serum stimulation-2 (ST2) and oxidised IL-33 (IL-33)/receptor for advanced glycation end products (RAGE)/epidermal growth factor receptor (EGFR) pathways. This study aimed to identify associations of IL-33 with clinical outcomes and pathological mechanisms during viral lower respiratory tract disease (LRTD). Ultra-sensitive immunoassays were developed to measure IL-33, IL-33 and IL-33/sST2 complexes in samples from patients hospitalised with COVID-19.
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- Scientists studied cancer cells to understand how some of their chromosomes don't behave correctly, which can lead to problems.
- They tried a new method using CRISPR technology to help find out how specific chromosomes could mis-segregate (go to the wrong place during cell division).
- Their experiments showed that this method can create instability in certain chromosomes, which could help researchers learn more about diseases related to aneuploidy (having the wrong number of chromosomes).