Publications by authors named "Mollie D Patton"
Article Synopsis
- COVID-19 is caused by the highly contagious SARS-CoV-2 virus, and detecting its proteins in infected tissues can aid in understanding its behavior and how it affects different body cells.
- Researchers have identified specific antibodies that effectively detect SARS-CoV-2 proteins through immunohistochemistry, with validated protocols based on lung tissue from deceased COVID-19 patients.
- These detection methods not only allow insights into viral distribution and clearance in human patients but are also adaptable for use in animal models and could help identify potential animal reservoirs of the virus.
Objectives: Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness.
Methods: Lungs of 12 consecutive COVID-19 decedents consented for autopsy were evaluated for gross and histopathologic abnormalities. A complete Ghon "en block" dissection was performed on all cases; lung weights and gross characteristics recorded.