Publications by authors named "Moli Fan"
Article Synopsis
- The study looked at how COVID-19, specifically the Omicron variant, affects patients with myasthenia gravis (MG), focusing on risk factors for severe infection and potential impacts on MG symptoms.
- Among 287 patients surveyed, it was found that factors like older age, existing health conditions, and instability of MG were linked to worse COVID-19 outcomes and increased myasthenic exacerbations post-infection.
- The results suggest that while MG patients are at higher risk for severe COVID-19, treatments for MG do not worsen infection severity, but instead a careful assessment of ongoing treatments is recommended rather than stopping them.
A Simple Score (MOG-AR) to Identify Individuals at High Risk of Relapse After MOGAD Attack.
Neurol Neuroimmunol Neuroinflamm
November 2024
Article Synopsis
- The study aimed to identify predictors for relapse in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and create a risk score to predict relapse.
- Researchers followed 188 patients from the China National Registry of Neuro-Inflammatory Diseases (CNRID) and found key factors such as female sex and age at onset that influence relapse risk.
- The developed MOG-AR score effectively predicts relapse risk, indicating that a score between 13-16 significantly correlates with a higher risk of relapse, suggesting the potential for better patient management and treatment strategies.
Progressive retinal neuroaxonal damage after acute optic neuritis may occur in neuromyelitis optica spectrum disorder (NMOSD). However, it is unclear if treatments used to prevent attacks influence neurodegeneration. We aimed to investigate retinal damage in patients treated with disease-modifying drugs in a longitudinal study.
View Article and Find Full Text PDFBackground: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy characterized by aquaporin-4 antibodies, whose prognosis is influenced by onset age, race, environmental exposures and immunosuppression. Distinguishing the contribution of environment from genetics is challenging. We aimed to compare neuromyelitis optica spectrum disorder (NMOSD) patient outcomes according to self-identified racial group and place of residence.
View Article and Find Full Text PDFBackground: Despite inclusion in neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated diseases are increasingly recognized as an independent disease entity. In this study, we conducted a systematic review and meta-analysis to comprehensively update the rate of occurrence of MOG-Ab in Aquaporin4 (AQP4)-antibody seronegative NMOSD.
Methods: We searched PubMed, EMBASE, and Cochrane databases for studies reporting the rates of patients with MOG-Ab in NMOSD.
In neuromyelitis optica spectrum disorders (NMOSDs), inflammation is not the sole driver of accumulation of disability; neurodegeneration is another important pathological process. We aim to explore different patterns of cortical atrophy and ventricular enlargement in NMOSD. We retrospectively analyzed a cohort of 230 subjects, comprising 55 healthy controls (HCs), 85 multiple sclerosis (MS), and 90 NMOSD patients from Tianjin Medical University General Hospital and Beijing Tiantan Hospital.
View Article and Find Full Text PDFIntravenous immunoglobulin for acute attacks in neuromyelitis optica spectrum disorders (NMOSD).
Mult Scler Relat Disord
September 2020
Background: During acute attacks of neuromyelitis optica spectrum disorder (NMOSD), intravenous immunoglobulin (IVIG) maybe useful building on experience treating autoimmune disorders.
Methods: We conducted a retrospective study of several treatment modes for NMOSD attacks at Beijing Tiantan Hospital and Tianjin Medical University General Hospital. Clinical outcomes were defined as the short-term remission status.
Objective: Disease-modifying drugs (DMDs) may alter the immune status and thus increase the susceptibility to coronavirus disease 2019 (COVID-19) in patients with MS or neuromyelitis optica spectrum disorders (NMOSD). However, evidence supporting this notion is currently lacking. In this study, we conducted a survey on the risk of COVID-19 in patients with MS and NMOSD.
View Article and Find Full Text PDFAims: Intracerebral hemorrhage (ICH) is a devastating type of stroke without specific treatment. Activator protein 1 (AP-1), as a gene regulator, initiates cytokine expression in response to environmental stimuli. In this study, we investigated the relationship between AP-1 and neuroinflammation-associated brain injury triggered by ICH.
View Article and Find Full Text PDFObjective: This study aims to investigate whether bidirectional degeneration occurs within the visual pathway and, if so, the extent of such changes in neuromyelitis optica spectrum disorder (NMOSD).
Methods: In total, 36 NMOSD and 24 healthy controls (HCs) were enrolled. Three-dimensional T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging were used to analyze damage to the posterior visual pathway.
Background: The spinal cord and brain measurements are rarely investigated in neuromyelitis optica (NMO) patients with and without antibodies to aquaporin-4 (AQP4), directly compared to multiple sclerosis (MS) patients.
Objectives: To investigate magnetic resonance imaging (MRI) features of both brain and spinal cord in NMO patients with and without antibodies to AQP4, compared with MS patients and healthy controls (HC).
Methods: We recruited 55 NMO including 30 AQP4 (+) and 25 AQP4 (-), 25 MS and 25 HC.
Objective: To identify the clinical and structural MRI markers for predicting cognitive impairment (CI) in patients with neuromyelitis optica (NMO).
Methods: Fifty-four patients with NMO and 27 healthy controls underwent extensive neuropsychological testing and multimodal 3.0T MRI.