Publications by authors named "Molen S"

Executive summary: The age of Canada's population is increasing, necessitating innovative methods and tools for assessing the needs of older adults and identifying effective health and social prescriptions. In Alberta, a community-based, senior-serving organization undertook the development and piloting of the Healthy Aging Asset Index, an assessment tool and social prescribing guide for use by a variety of professionals within the community. Tool development was rooted in medical complexity assessment and social work practice, and adhered to the determinants of healthy aging established by Alberta's Healthy Aging Framework, which is based on the determinants of healthy aging published by the World Health Organization.

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Introduction: Burn injury is a major cause of mortality. Majority of the burns occur in low and middle-income countries like Uganda. Uganda has a limited number of burn centres and medical resources, making a predictor of mortality necessary in allocation of the limited resources.

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  • Secondary peritonitis is a significant cause of sepsis globally, particularly in resource-limited areas like Uganda, prompting a study to assess bacterial infections and susceptibility among surgical patients.
  • Conducted at Hoima Regional Referral Hospital, the study involved 126 patients, identifying that 45.2% had secondary peritonitis, with Escherichia coli and Klebsiella spp being the most common bacteria isolated.
  • Results indicated that certain antibiotics, like Imipenem and Amikacin, were effective against these infections, and males or those presenting late after symptom onset were more likely to have secondary peritonitis, emphasizing the need for early medical attention.
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Introduction: Surgery for acute appendicitis has been associated with significant morbidity. This study aimed to determine the factors associated with early inhospital adverse outcomes following surgery for acute appendicitis in Uganda.

Methods: This was a multicentre, prospective cohort in which early inhospital outcome following surgery for acute appendicitis was assessed at 4 regional referral hospitals in Uganda.

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  • Epidermolysis bullosa (EB) is a genetic skin condition that causes blistering due to mutations in proteins that help bind skin layers together.
  • A study tracked 15 patients with recessive dystrophic or junctional EB, analyzing their blood for autoantibodies related to autoimmune blistering diseases.
  • Results showed that patients with recessive dystrophic EB had a significantly higher chance (70%) of developing these autoantibodies compared to those with junctional EB (20%), with reactivity most notably against specific collagen types and other proteins.
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  • In 2015, the Dutch research council implemented changes to address gender bias in their Talent Programme, which offers grants for researchers at different career stages.
  • The study investigates whether these measures successfully eliminated gender disparities in grant funding by analyzing data from over 16,000 applications submitted since 2012.
  • Findings reveal that female applicants now have a higher likelihood of receiving the initial Veni grant, indicating a shift in gender effects, although significant disparities persist in the later Vidi and Vici tiers.
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  • Single fluorescent molecules in host crystals are effective probes for studying dynamics at the nanoscale, particularly due to their fine optical linewidth at low temperatures.
  • However, these linewidths significantly increase when molecules are near surfaces, with no 0-0 zero-phonon line (ZPL) observed on surfaces until now.
  • This study successfully detects the 0-0 ZPL of terrylene molecules on hexagonal boron-nitride surfaces, showing improved spectral stability in molecules on annealed flakes compared to non-annealed ones.
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  • A study was conducted in Uganda comparing the costs and efficiency of open hemorrhoidectomy (OH) procedures using local anesthesia (LA) versus saddle block (SB) for patients with severe hemorrhoids (3rd or 4th degree).
  • The trial involved 58 patients and found that surgery using LA resulted in a significantly shorter operating time (15.5 minutes) and was less expensive ($57.42) compared to SB (33.7 minutes and $63.38).
  • The researchers concluded that using LA is more cost-effective and can help increase patient turnover in low-income countries, suggesting that policymakers should prioritize this method to meet global surgery goals by 2030.
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  • Connectomics, a method that utilizes large-volume serial electron microscopy, is an essential tool for understanding neural circuits.
  • Current imaging techniques like transmission electron microscopy (TEM) and scanning electron microscopy (SEM) have limitations in achieving synaptic resolution.
  • The introduction of photoemission electron microscopy (PEEM) offers a new approach that combines fast imaging with high resolution, allowing for efficient circuit mapping in neuroscience.
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Introduction: Testicular torsion refers to ischemia of the testicle due to twisting or rotation of the vessels supplying the testes. It is a urologic emergency requiring a high index of clinical suspicion and prompt surgical intervention with management aimed at avoiding testicular loss and resulting infertility. This paper gives an update on the current situation regarding this topic in low-income settings.

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The recent observation of correlated phases in transition metal dichalcogenide moiré systems at integer and fractional filling promises new insight into metal-insulator transitions and the unusual states of matter that can emerge near such transitions. Here, we combine real- and momentum-space mapping techniques to study moiré superlattice effects in 57.4° twisted WSe_{2} (tWSe_{2}).

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A new, complementary technique based on Photo Emission Electron Microscopy (PEEM) is demonstrated. In contrast to PEEM, the sample is placed on a transparent substrate and is illuminated from the back side while electrons are collected from the other (front) side. In this paper, the working principle of this technique, coined back-illuminated PEEM (BIPEEM), is described.

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  • The paper discusses a new cryogenic sample chamber designed for low energy electron microscopy (LEEM) and shares initial experimental findings.
  • Modifications were made to the LEEM instrument to enable cooling mechanisms and minimize heat load, achieving sample temperatures as low as 15 K using liquid nitrogen and helium.
  • Initial low-temperature LEEM experiments on a three-monolayer pentacene film revealed a significant decrease in electron beam damage at lower temperatures and changes in the LEEM-IV spectra, with explanations provided for these observations.
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  • The LEEM-IV spectra of few-layer graphene reveal specific energy minima that vary with the number of layers, while low-energy TEM spectra show transmission maxima at those corresponding energy levels.
  • The observed patterns in both LEEM and TEM can be explained through electron wave function interference in an elastic scattering model.
  • A new model is proposed that incorporates both elastic and inelastic scattering effects, allowing for a self-consistent extraction of Mean Free Path (MFP) values and a comparison with existing research.
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Introduction: Surgical site infection (SSI) is the commonest form of hospital acquired infection in sub-Saharan Africa, associated with increased morbidity and mortality. This study was aimed at determining the incidence and outcomes of surgical site infection following emergency laparotomy during the COVID -19 pandemic in a low resource setting.

Methods: This was a retrospective single Centre cohort of patients that had emergency laparotomy between July 2021-June 2022 (COVID period) and July 2018-June 2019 (pre-COVID period).

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Unlabelled: Even though urolithiasis in general is not uncommon, urethral stones have an incidence of less than 0.3% and are 20 times less common in children. Though cases of urethral stones have been reported in children from endemic areas, they are even rarer in countries like Uganda that are not endemic for urolithiasis.

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Background: Prolonged post-operative ileus is associated with increased risk of other complications, length of hospital stays and health care related costs. Chewing gum has been shown to reduce duration of ileus in many elective surgeries, but there is a paucity of randomised controlled trials (RCTs) on its effect on duration of ileus among patients undergoing emergency surgery, specifically patients with peritonitis. The aim of this study is to determine the effect of chewing gum on duration of postoperative ileus following laparotomy for gastroduodenal perforations.

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  • In 'magic angle' twisted bilayer graphene, a flat band leads to correlated insulating behavior and superconductivity, but the variable moiré structure affects device conductance.
  • By employing aberration-corrected Low Energy Electron Microscopy, researchers found smaller spatial variations in the moiré pattern than earlier studies and observed thermal fluctuations of collective atomic displacements.
  • The study determined that thermal annealing can reduce local disorder without any untwisting detected at temperatures up to 600°C, and identified edge dislocations that may reveal unique electronic properties.
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Crystalline films of pentacene molecules, two to four monolayers in thickness, are grown via in situ sublimation on silicon substrates in the ultrahigh vacuum chamber of a low-energy electron microscope. It is observed that the diffraction pattern of the pentacene layers fades upon irradiation with low-energy electrons. The damage cross section is found to increase by more than an order of magnitude for electron energies from 0 to 10 eV and by another order of magnitude from 10 to 40 eV.

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  • Transmission electron microscopy at very low energy reduces damage to sensitive biological samples by using a modified setup with an additional electron source for imaging in the 0-30 eV range.
  • The technique, demonstrated with materials like free-standing graphene, achieves imaging and spectroscopy in both transmission and reflection modes at nanometer resolution.
  • Notable results include detailed images of gold nanoparticles and DNA origami rectangles, showing the potential of eV-TEM for safe, high-resolution imaging of biological samples.
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For many complex materials systems, low-energy electron microscopy (LEEM) offers detailed insights into morphology and crystallography by naturally combining real-space and reciprocal-space information. Its unique strength, however, is that all measurements can easily be performed energy-dependently. Consequently, one should treat LEEM measurements as multi-dimensional, spectroscopic datasets rather than as images to fully harvest this potential.

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  • Extreme ultraviolet (EUV) lithography is a cutting-edge technology enabling the creation of tiny electronic circuits under 20 nm in size, with low-energy electrons (LEEs) playing a key role in this process.
  • Researchers used advanced techniques like LEE microscopy, electron energy loss spectroscopy, and atomic force microscopy to examine how electrons in the range of 0-40 eV affect a specific EUV resist material, revealing that even very low-energy electrons can trigger significant chemical reactions.
  • A proposed reaction model suggests that a small quantity of electrons (about 10 per molecule) is sufficient to render the resist material insoluble, aligning with the observed sensitivity of tin-oxo cage materials in EUV lithography.
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The two-dimensional electron liquid which forms between the band insulators LaAlO (LAO) and SrTiO (STO) is a promising component for oxide electronics, but the requirement of using single crystal SrTiO substrates for the growth limits its applications in terms of device fabrication. It is therefore important to find ways to deposit these materials on other substrates, preferably Si, or Si-based, in order to facilitate integration with existing technology. Interesting candidates are micron-sized nanosheets of CaNbO which can be used as seed layers for perovskite materials on any substrate.

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In contrast to the in-plane transport electron mean-free path in graphene, the transverse mean-free path has received little attention and is often assumed to follow the "universal" mean-free path (MFP) curve broadly adopted in surface and interface science. Here we directly measure transverse electron scattering through graphene from 0 to 25 eV above the vacuum level both in reflection using low energy electron microscopy and in transmission using electronvolt transmission electron microscopy. From these data, we obtain quantitative MFPs for both elastic and inelastic scattering.

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