ECHOCARDIOGRAPHIC PREDICTORS OF THE EARLY POSTOPERATIVE PERIOD IN PATIENTS AFTER CORONARY ARTERY BYPASS GRAFT SURGERY.

Objective: The aim: The purpose of the present research was to study the results of coronary artery bypass graft (CABG) surgery depending on the degree of left ventricular ejection fraction (LVEF) reduction with the aim to identify additional echocardiographic predictors of the early postoperative period.

Patients And Methods: Materials and methods: Were fixed, the results of CABG in 97 patients operated on in the "Bikard" private clinic from March 2016 to December 2018 were the material of the research. All patients underwent CABG surgery under cardiopulmonary bypass and cardioplegia, and in the preoperative period underwent echocardiographic examination according to the standard technique on the Vivid 7 machine.

[Role of methyltetrahydrofolate reductase (MTHFR) gene polymorphism in the development of ischemic stroke in the dwellers of the Kyrgyz Republic].

Aim: To study the role of MTHFR gene polymorphism in patients with ischemic stroke (IS) in the Kyrgyz Republic.

Subjects And Methods: Molecular genetic testing of C677T polymorphism in the MTHFR gene was carried out in 107 Kyrgyz patients with prior IS. The patients were grouped according to the severity of motor impairments and the level of blood pressure (BP).

[Efficiency of combined resort rehabilitation of patients with cerebral stroke under the conditions of a medium-altitude region].

A comparative study of the effectiveness of the early rehabilitative treatment of post-stroke patients in a specialized hospital located in a medium-altitude mountainous area and in an outpatient clinic in the city of Bishkek (low altitude) was carried out. A more noticeable positive dynamics of the disturbed motor function and quality of life was documented in the patients treated in the mid-altitude in-patient hospital.

[Effect of altitude on blood oxygenation during sleep in patients with bronchial asthma].

The aim of our study was to investigate the severity of overnight arterial blood desaturations in patients with asthma at the altitude of 3200 meters above sea level. 12 asthmatics and 12 healthy controls were investigated. Three overnight pulsoximetries were performed in all subjects, one at the lowland and on the 1st and 5th night at the altitude.

[The clinico-functional characteristics of pulmonary arterial hypertension in systemic scleroderma].

Electro-, phono-, echo-, and Doppler echocardiography, bulbar biomicroscopy were performed in 54 SS patients aged 18-64. Mean pulmonary arterial pressure (PP) was determined at Doppler echocardiography on Toshiba SSH-40A unit according to techniques developed by M. M.

Effects of acetazolamide on overnight oxygenation and acute mountain sickness in patients with asthma.

The aim of the study was to assess effects of acetazolamide in prevention of acute mountain sickness (AMS) and on overnight oxygenation, in patients with asthma treated at the altitude of 3,200 m. Sixteen patients with asthma, 6 males and 10 females, mean age 32 yrs, were first investigated at low altitude (760 m). They presented with mild airways obstruction, normal arterial blood gases, and normal oxygenation at night studied by pulse oximetry.

New approaches to noninvasive assessment of pulmonary artery pressure.

Direct measurement of pulmonary artery pressure (PAP) was performed in 36 patients; right ventricular (RV) isovolumic relaxation time (IRT) and RV systolic output acceleration time (AcT) values were assessed by pulsed Doppler and 2-M echocardiography. There was a fairly good correlation between RV IRT and systolic PAP (r = 0.898; SEE = 7.

[Functional state of the left heart in aortic regurgitation of varying degrees].

An attempt was made to noninvasively assess the myocardial reserve by using a bimanual isometric exercise (BIE) in patients with aortic failure depending on the degree of aortic regurgitation (AR). The patients with Grade I AR, like healthy subjects, showed their responses to BIE, by significantly enhancing systolic BP, heart rate (HR), left ventricular ejection fraction (LVEF), stroke index and decreasing the end systolic volume of the left ventricle, which indicated that the left ventricle had great compensatory potentialities. With physical exercise, the patients with Grade II AR displayed an inadequately small increase in LVEF and velocity of myocardial circular fiber contractions, which suggested latent ventricular failure and was an indicator of diminished myocardial reserve.

[Clinico-functional characteristics of minimally pronounced aortal insufficiency].

Fifty-five patients with "pure" aortal failure (AF) aged 16 to 48 years were examined. There were 39 men and 16 women. Of these, 22 patients presented with minimal, 20 with moderate, and 13 with pronounced AF.

[Characteristics of the pharmacotherapy of chronic heart failure under high-altitude conditions].

A study was made of the peculiarities of therapy of chronic heart failure (CHF) resulting from rheumatic heart disease under low-altitude (200 patients) and high-altitude (139 patients) conditions using strophanthin (76 patients), digoxin (76 patients), myofedrin (30 patients), nitroglycerin (43 patients), nitrong (35 patients), corvaton (46 patients), hydralazine (40 patients), nifedipine (52 patients), and verapamil (31 patients). It was shown that glycoside intoxication was twice as frequent in the patients with severe CHF under high-altitude conditions requiring the use of lower doses of cardiac glycosides and more thorough medical control. Better response to nitrates, corvaton, hydralazine, and nifedipine in multimodality treatment of CHF was found in mountain dwellers.

[Noninvasive assessment of the function of the lesser circulation and of the right heart in mitral stenosis].

Functional status of the pulmonary circulation network and the right compartments of the heart was assessed by two-dimensional Doppler echocardiography at rest and under isometric stress (handgrip with both hands) in 36 patients with varying degrees of mitral stenosis. An early stage of the condition is characterized by hyper-reactivity of the pulmonary circulation vessels as well as intact right-ventricular contractility. Hypertensive response of the pulmonary circulation vessels in combination with inadequately small increase in right-ventricular contractility are suggestive of an early stage of right-ventricular heart failure.

[The use of corinfar in combined treatment of congestive heart failure at high altitude].

Altogether 52 patients with severe forms of congestive cardiac failure (CCF) developing as a result of rheumatic valvular heart diseases, were examined. The patients were divided into 2 groups: 35 living permanently in the lowlands (LL) and 17 living in the highlands (HL). All the patients received corinfar (nifedipine) as part of multimodality therapy at a single dose of 20 mg/m2 with 8-h intervals for 10 days.

[Mitral valve prolapse in residents of different altitudes in the Tien Shan and Pamirs].

A study was made of mitral valve prolapse (MVP) in 1197 Kirghiz mountain-dwellers aged 16 to 22 living constantly at different altitudes of the Tien Shan and the Pamirs. MVP was detected in 24 persons (10.9%) living at an altitude of 3600-4200 m above sea level using the method of echocardiography.

[Hemodynamic effects of molsidomine in patients with cardiac insufficiency at high altitudes].

Central hemodynamic effects of 0.05 mg/kg molsidomine were examined in 60 patients with decompensated mitral disease dwelling at low and medium altitudes. M-echocardiography was used to assess hemodynamic shifts.

[Syndrome of high-altitude hypertrophic cardiomyopathy].

The authors report the clinical, ECG, PCG and echocardiography data obtained in mountaineers suffering from associated essential hypertension and high-altitude pulmonary hypertension. Demonstrate the advisability of distinguishing the high-altitude hypertrophic cardiomyopathy syndrome (HHCS) in part of mountaineers with essential hypertension living permanently at an altitude of 3600-4200 m over the sea level. The HHCS is marked by a lot of the clinical and echocardiographic signs which are regarded as characteristic of hypertrophic cardiomyopathy, particularly by appreciable asymmetrical hypertrophy of the interventricular septum.