Publications by authors named "Moksh Shah"
Cyclooxygenase-2 (COX-2), a key enzyme in the cyclooxygenase family, is pivotal in producing pro-inflammatory prostaglandins, driving chronic inflammation and related disorders. Targeting COX-2 with selective inhibitors can mitigate these conditions while avoiding the gastrointestinal and hepatotoxic/nephrotoxic side effects of traditional NSAIDs. However, the selectivity towards COX-2 inhibition has been associated with cardiovascular risks, necessitating the discovery of novel molecular scaffolds avoiding CVS side effects.
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- Researchers are focusing on DprE1, a key enzyme in tuberculosis that is difficult to target due to its size and location, as a potential target for new anti-tuberculosis drugs.
- Benzothiazinone has shown promise as a pharmacophore for inhibiting DprE1, with several clinical trial drugs achieving promising results.
- A study developed a robust 3D QSAR model to identify effective Benzothiazinone derivatives, alongside docking studies that supported the design of new compounds aimed at combating tuberculosis.
Article Synopsis
- Multi-target directed ligands (MTDLs) are being researched for their effectiveness against Alzheimer's disease by addressing multiple aspects of the condition, like enzyme inhibition and metal balance.
- The study synthesized piperazine-quinoline-based MTDLs using a specific chemical reaction and found that certain compounds showed strong activity against the enzymes AChE and BuChE.
- Among the compounds, compound (95) showed the best inhibitory effects on both enzymes, while also demonstrating antioxidant properties and metal-chelating abilities, suggesting it could be a promising candidate for further Alzheimer's research.