Design, synthesis, and bioevaluation of novel unsaturated cyanoacetamide derivatives: In vitro and in silico exploration.

In this study, we synthesized novel α,β-unsaturated 2-cyanoacetamide derivatives () using microwave-assisted Knoevenagel condensation. Characterization of these compounds was carried out using FTIR and H NMR spectroscopy. We then evaluated their in vitro antibacterial activity against both gram-positive and gram-negative pathogenic bacteria.