Publications by authors named "Mokryun Baek"
Article Synopsis
- Mitochondria are important parts of cells that help with energy and can influence cancer growth and how well treatments work.
- Researchers studied a type of aggressive breast cancer called triple negative breast cancer (TNBC) to understand how the structure of mitochondria changes when treated with chemotherapy.
- They found that chemotherapy can change the shape and size of mitochondria in tumors, differing in treated tumors compared to those that weren't treated, suggesting that understanding these changes could help improve cancer treatment strategies.
Article Synopsis
- Cisplatin (CDDP) is commonly used to treat advanced head and neck cancers, but many tumors develop resistance through changes in their metabolism.
- Researchers studied CDDP-resistant cancer cell clones using advanced techniques, revealing that mutations in KEAP1 lead to increased Nrf2 activity, which is linked to drug resistance.
- The study found that resistant cells show metabolic shifts that reduce energy production while enhancing biomass generation, suggesting new potential treatments could target these specific metabolic pathways.
Article Synopsis
- * Research showed that residual TNBC cells depend heavily on mitochondrial oxidative phosphorylation (OXPHOS) for survival after treatment, with mitochondrial structure and dynamics influencing this reliance.
- * Using a combination of DNA-damaging chemotherapy to increase mitochondrial fusion and OXPHOS followed by an OPA1 inhibitor successfully suppressed the regrowth of remaining TNBC tumor cells, suggesting a new treatment strategy.
Methodological Advancements for Investigating Intra-tumoral Heterogeneity in Breast Cancer at the Bench and Bedside.
J Mammary Gland Biol Neoplasia
December 2020
There is a major need to overcome therapeutic resistance and metastasis that eventually arises in many breast cancer patients. Therapy resistant and metastatic tumors are increasingly recognized to possess intra-tumoral heterogeneity (ITH), a diversity of cells within an individual tumor. First hypothesized in the 1970s, the possibility that this complex ITH may endow tumors with adaptability and evolvability to metastasize and evade therapies is now supported by multiple lines of evidence.
View Article and Find Full Text PDFCircadian clocks generate rhythms in cellular functions, including metabolism, to align biological processes with the 24-hour environment. Disruption of this alignment by shift work alters glucose homeostasis. Glucose homeostasis depends on signaling and allosteric control; however, the molecular mechanisms linking the clock to glucose homeostasis remain largely unknown.
View Article and Find Full Text PDFBackground: Efficient gene editing is a critical tool for investigating molecular mechanisms of cellular processes and engineering organisms for numerous purposes ranging from biotechnology to medicine. Recently developed RNA-guided CRISPR/Cas9 technology has been used for efficient gene editing in various organisms, but has not been tested in a model filamentous fungus, .
Findings: In this report, we demonstrate efficient gene replacement in a model filamentous fungus, , with the CRISPR/Cas9 system.
Autonomous circadian oscillations arise from transcriptional-translational feedback loops of core clock components. The period of a circadian oscillator is relatively insensitive to changes in nutrients (e.g.
View Article and Find Full Text PDFThe cell cycle and the circadian clock communicate with each other, resulting in circadian-gated cell division cycles. Alterations in this network may lead to diseases such as cancer. Therefore, it is critical to identify molecular components that connect these two oscillators.
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