Publications by authors named "Mojtaba Nemati"
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using optical clearing and imaging, we observed the accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients, persisting long after viral clearance. Further, biomarkers of neurodegeneration were elevated in the cerebrospinal fluid from long COVID patients, and proteomic analysis of human skull, meninges, and brain samples revealed dysregulated inflammatory pathways and neurodegeneration-associated changes.
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- Multiple system atrophy (MSA) is a neurodegenerative disease characterized by abnormal protein aggregation, resulting in symptoms like dysautonomia, parkinsonism, and ataxia.
- This study aimed to assess the accuracy of diagnostic criteria for MSA, emphasizing the role of new MRI markers in diagnosis.
- Results showed that while the criteria had high specificity (99-100%), their sensitivity was low initially but improved over time; excluding MRI features from the criteria significantly increased sensitivity without affecting specificity.