Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic-Assisted Approaches Toward Smart Cancer Diagnosis and Analysis.

Exosomes are essential indicators of molecular mechanisms involved in interacting with cancer cells and the tumor environment. As nanostructures based on lipids and nucleic acids, exosomes provide a communication pathway for information transfer by transporting biomolecules from the target cell to other cells. Importantly, these extracellular vesicles are released into the bloodstream by the most invasive cells, i.

Importance of STAT3 Polymorphisms on the Risk and Clinical Characteristics of Rheumatoid Arthritis.

Signal transducer and activator of transcription 3 (STAT3) has been introduced as one of the critical genetic factors in the pathogenesis of rheumatoid arthritis (RA). Single nucleotide polymorphisms (SNPs) in microRNA binding sites, known as miRSNPs, are a class of common variants in the 3' untranslated regions of genes targeted by miRNAs. miRSNPs unbalance gene expression by disrupting the binding regions of microRNAs.

Ultra-precise label-free nanosensor based on integrated graphene with Au nanostars toward direct detection of IgG antibodies of SARS-CoV-2 in blood.

Rapid distribution of airborne contagious pathogenic viruses such as SRAS-CoV-2 and their severely adverse impacts on different aspects of the human society, along with significant weaknesses of traditional diagnostic platforms, raised the global requirement for the design/fabrication of precise, sensitive, and rapid nanosystems capable of specific detection of viral illnesses with almost negligible false-negative results. To address this indispensable requirement, we have developed an ultra-precise fast diagnostic platform capable of detecting the trace of monoclonal IgG antibody against S1 protein of SARS-CoV-2 within infected patients' blood specimens with COVID-19 in about 1 min. The as-developed electrochemical-based nanosensor consists of a highly activated graphene-based platform in conjunction with Au nanostars, which can detect SARS-CoV-2 antibodies with a fantastic detection limit (DL) and sensitivity of 0.

The Effect of on Renal Oxidative Injury in Diabetic Rats.

Oxidative stress plays a key role in the evolution of diabetes complications. The current study looked into the potential effects of the hydroalcoholic extract of Nigella sativa on the oxidative injury of the rat kidneys in diabetic animals. The animals were placed into five study groups in a random manner as follows: (1) control, (2) diabetic, (3 and 4) treatment with two doses of N.

Erythrosine Adsorption from Aqueous Solution via Decorated Graphene Oxide with Magnetic Iron Oxide Nano Particles: Kinetic and Equilibrium Studies.

In this research, first graphene oxide (GO) was synthesized using modified Hummers method and thence via a multi-step procedure, surface of GO was decorated with Fe3O4 nanoparticles (GO-Fe3O4). Thereafter, developed nanoparticles were characterized using FTIR, XRD and SEM analyses and their magnetic properties confirmed using VSM analysis. Moreover, performance of the GO-Fe3O4 for the removal and adsorption of Erythrosine dye from the aqueous solution under variable conditions including pH, phosphate buffer solution (PBS), adsorbent content, stirring time, electrolyte concentration, solution content and temperature were examined.

Synthesis of Fe3O4 Nanoparticles Modified by Oak Shell for Treatment of Wastewater Containing Ni(II).

In present study, removal of nickel ions (Ni (II)) from synthetic wastewater using Fe3O4 nanoparticles modified by oak shell was investigated. The FTIR analysis of the adsorbent suggested the occurrence of interaction between the carboxyl group on oak shell modified magnetic nanoparticles (OSMMN) surface and Ni (II). Also, the morphology and size of the adsorbent were observed by SEM and TEM.

Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats.

Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods.