Publications by authors named "Mojtaba Mohammadpanah"
Article Synopsis
- The study investigated how 10 mg/kg of Δ9-tetrahydrocannabinol (THC) affects brain cells in the cerebellum of male Wistar rats using various histological techniques.
- THC treatment resulted in a significant decrease in Purkinje neuron numbers and granular layer thickness, along with signs of inflammation and changes in microglial and astrocyte morphology.
- The findings suggest that THC may have both neuroprotective and neurodegenerative effects, indicating the need for further research in this area.
Tetrahydrocannabinol (THC), a major psychoactive constituent of marijuana, can substantially change the function of several brain areas, leading to behavioral impairment including memory and learning dysfunction. Given the importance of hippocampus as one of the chief parts of the brain involved in memory processing, the present study seeks to investigate structural and histological alterations in hippocampus as well as behavioral defects provoked by THC treatment. Besides, using genome-wide sequencing, we adopted a pathway-based approach to discover dysregulated molecular pathways.
View Article and Find Full Text PDF