Publications by authors named "Mojtaba Malek"
Article Synopsis
- A study was conducted on 1,368 COVID-19 patients in Tehran to evaluate how comorbidities impact the risk of in-hospital death and serious outcomes.
- Findings revealed that patients with diabetes and chronic kidney disease had significantly higher mortality rates during hospitalization.
- The research concluded that nonelderly patients (under 65) with two or more comorbidities are at a greater risk of dying in the hospital, highlighting the need for targeted prevention strategies in this group.
Article Synopsis
- - The study explores the connection between microRNA miR-141, Sirtuin 1 (SIRT1), and non-alcoholic fatty liver disease (NAFLD) in adults, finding significant changes in these factors related to obesity and metabolic health.
- - In a group of 100 adults, it was revealed that miR-141 levels were higher and SIRT1 expression was lower in those with obesity compared to normal-weight individuals, indicating a negative relationship between the two.
- - The findings suggest that increased miR-141 could inhibit SIRT1, leading to obesity-related issues like NAFLD, highlighting the potential of miR-141 as a target for diagnosis and treatment in these conditions.
Background: Radioactive iodine (RAI) therapy is the standard treatment approach after total thyroidectomy in patients with papillary thyroid carcinoma (PTC). We aimed to identify predictive factors of response to the treatment in intermediate and high-risk patients with PTC. In addition, the impact of multiple RAI treatments was explored.
View Article and Find Full Text PDFBackground: There is little information about the effect of single nucleotide polymorphisms (SNP) and nutritional status and weight loss after bariatric surgery. This study investigated the interactive effect of eight obesity-related SNPs and nutritional status on weight loss after Roux-en-Y gastric bypass (RYGB).
Method: This is a case-control study.
Article Synopsis
- Researchers evaluated the effectiveness of various insulin resistance (IR) and sensitivity (IS) measures in identifying metabolic-associated fatty liver disease (MAFLD) and liver fibrosis in a cross-sectional study involving 644 individuals aged 25-75.
- The study found that 49.7% of participants had MAFLD, and 12.4% had significant liver fibrosis, with TyG-WC, TyG-BMI, and TyG-WHtR emerging as the top indicators for MAFLD detection.
- Additionally, insulin-based measures like HOMA-IR and QUICKI performed best in identifying liver fibrosis across different demographic groups, regardless of age, gender, obesity, or diabetes status.
Background: The aim of this study was to compare moderate- versus high-intensity statin therapy in patients with type 2 diabetes and low-density lipoprotein (LDL) cholesterol less than 130 mg/dL.
Methods: This was a randomized, open-label, parallel design trial comprised of 79 patients randomly allocated into two groups receiving high-intensity [atorvastatin 40 mg (A40) or rosuvastatin 20 mg (R20) daily] or moderate-intensity [atorvastatin 20 mg (A20) or rosuvastatin 10 (R10) mg daily] statins for eight weeks. The variables investigated were lipid profile, high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6).
Introduction: Pharmacogenetics studies suggest that genetic variants have a possible influence on the inter-individual differences in therapeutic response to glucagon-like peptide 1 receptor agonists (GLP-1 RAs). We aimed to examine the potential role of genetic variability of glucagon-like peptide 1 receptor (GLP-1R) on glycemic response to GLP-1 RAs in a population of Iranian people with type 2 diabetes mellitus (T2DM).
Methods: In this study, we analyzed the data from participants in a non-inferiority randomized clinical trial between 2019 and 2020.
Body composition is related to cardiometabolic disorders and is a major driver of the growing incidence of type 2 diabetes mellitus (T2DM). Altered fat distribution and decreased muscle mass are related to dysglycemia and impose adverse health-related outcomes in people with T2DM. Hence, improving body composition and maintaining muscle mass is crucial in T2DM.
View Article and Find Full Text PDFIntroduction: Nonalcoholic fatty liver disease (NAFLD) frequently coexists with type 2 diabetes mellitus (T2DM) and synergistically contributes to the development of atherosclerosis. Flow-mediated dilation (FMD) is a commonly used noninvasive test for assessing endothelial function. The main objective of this study was to explore FMD in patients with T2DM with and without NAFLD.
View Article and Find Full Text PDFBackground: Nonalcoholic fatty liver disease (NAFLD) is a complex metabolic disorder that increases the risk for cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Global longitudinal strain (GLS) is an indicator of left ventricular (LV) mechanics and can detect subclinical myocardial dysfunction. We compared the effects of pioglitazone and empagliflozin on GLS in patients with T2DM and NAFLD without established atherosclerotic cardiovascular disease.
View Article and Find Full Text PDFIntroduction: Liraglutide effectively controls blood glucose level and reduces body weight. The aim of this study was to compare the efficacy and safety of a biosimilar liraglutide (Melitide; CinnaGen, Tehran, Iran) to the reference liraglutide (Victoza; Novo Nordisk, Bagsvaerd, Denmark) in people with type 2 diabetes mellitus (T2DM).
Methods: In this phase 3 clinical noninferiority trial, adult patients with inadequately controlled T2DM and with hemoglobin A (HbA) levels of 7-10.
Article Synopsis
- The study investigated the effects of Melissa officinalis (M. officinalis) extract on depression, anxiety, and sleep quality in type 2 diabetes patients experiencing depressive symptoms.
- In a double-blind clinical trial with 60 participants, those taking 700 mg/day of M. officinalis showed significant reductions in depression and anxiety scores after 12 weeks compared to the control group receiving a placebo.
- Despite improvements in mental health, no significant changes were observed in fasting blood sugar, inflammation markers, sleep quality, or other physical health metrics.
Background & Objective: High prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus results in deleterious complications and morbidities related to both diseases. Thus, we aimed to investigate dietary and anthropometric risk factors for progression of Non-alcoholic Fatty Liver Disease (NAFLD) in diabetic people.
Methods: Anthropometric, and dietary intakes, and hepatic steatosis and fibrosis were assessed in two hundred participants with type two diabetes (T2DM).
Article Synopsis
- The study aimed to explore the relationship between the monocyte/high-density lipoprotein cholesterol ratio (MHR) and carotid intima-media thickness (CIMT) in individuals with type 2 diabetes.
- Researchers measured various health indicators in 118 diabetics and 126 non-diabetics, finding that MHR and CIMT were similar across both groups.
- The analysis showed a significant correlation between MHR and CIMT specifically in male diabetics, suggesting that MHR could predict CIMT in this subgroup.
Predictive ability of six obesity measures to identify 7-year fatal and non-fatal cardiovascular events: A population-based cohort study.
Int J Cardiol Cardiovasc Risk Prev
September 2022
Background: Globally, most people die from cardiovascular diseases. We aimed to compare predictive ability of six obesity indices, including body mass index, waist circumference, waist-to-hip ratio, waist-to-height ratio, conicity index, and abdominal volume index, to identify people at risk of fatal and non-fatal cardiovascular events, in a cohort study.
Methods: We studied 5147 participants in a baseline population-based cohort study conducted in northern Iran.
Background: COVID-19 was introduced by the World Health Organization (WHO) as a global pandemic. The disease manifestations ranges from a mild common cold to severe disease and death. It has a higher mortality rate in people with a history of comorbidities, including cardiovascular disease (CVD) and can also contribute to cardiac injury.
View Article and Find Full Text PDFType 2 diabetes (T2D) is a progressive disease that should be managed with insulin in case of oral glucose lowering drugs (OGLDs) failure. If basal insulin is not sufficient, rapid acting insulin will be added before the largest meal. We assessed the impact of adding one prandial insulin to a basal based regimen and insulin glargine in patients with type 2 diabetes to measure the percentage of subjects achieving the HbA1c target by the end of 24 weeks of treatment in routine clinical practice.
View Article and Find Full Text PDFBackground: Gestational diabetes mellitus (GDM) is a major pregnancy endocrine problem that has several confirmed risk factors and is associated with adverse pregnancy-related outcomes (PRO).
Objective: To evaluate the relationship between GDM diagnosis and the associated risk factors of PRO (maternal, intrapartum, perinatal, and neonatal) in accordance with International Association of Diabetes and Pregnancy Study Groups criteria.
Materials And Methods: This prospective cohort study was performed with 531 singleton parturient (265 GDM and 266 non-GDM).
Background: The triglyceride-glucose index (TyG), and TyG-driven parameters incorporating TyG and obesity indices have been proposed as reliable indicators of insulin resistance and its related comorbidities. This study evaluated the effectiveness of these indices in identifying hepatic steatosis in individuals with Type 2 diabetes (T2DM).
Methods: This was a cross-sectional study consisting of 175 patients with T2DM (122 with and 53 without NAFLD).
Article Synopsis
- Metabolic issues are common in patients with acromegaly, but the role of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in these problems is not fully understood.
- This study analyzed data from 102 acromegaly patients post-surgery to see how GH/IGF-1 levels affected their metabolic health, particularly looking at blood sugar and blood pressure changes.
- Results showed that higher GH levels were linked to increased fasting blood glucose and blood pressure levels, and GH was identified as a predictor for diabetes, whereas IGF-1 did not show a significant impact on hypertension or dyslipidemia.
Background: It has been shown that a subgroup of patients with differentiated thyroid cancer (DTC) and medullary thyroid carcinoma (MTC) would progress to advanced stages of thyroid cancer. Therefore, the present study was done to systematically review available evidence in order to investigate efficacy and safety of peptide receptor radionuclide therapy (PRRT) in the patients with advanced radioiodine refractory differentiated thyroid cancer (RR-DTC) and metastatic MTC.
Methods: For this purpose, relevant studies investigated safety and efficacy of PRRT in the patients with advanced RR-DTC and metastatic MTC were identified by searching Medline (Pubmed, Ovid, and Ebsco), Scopus, Embase, Web of Science, and Cochrane Library databases (from database inception to March 24, 2021).
Article Synopsis
- NAFLD is prevalent among individuals with type 2 diabetes (T2DM), with higher grades of hepatic steatosis and significant fibrosis observed in diabetic patients compared to non-diabetics.
- The study analyzed 200 individuals, finding that those with T2DM had notably higher CAP scores and more severe liver conditions, including a greater incidence of advanced fibrosis.
- Factors like obesity, particularly central obesity, female gender, and elevated liver enzymes were significant predictors of advanced liver disease in T2DM patients.
Background: We sought to estimate the prevalence of diabetes mellitus (DM) and pre-DM and their associated factors among a sample of the Iranian urban population between 2017 and 2019.
Methods: The present investigation is a sub-study on the HAMRAH cohort study, a longitudinal population-based cohort study to assess the 10-year risk of cardiovascular diseases and their related risk factors in the adult population of the Iranian capital, Tehran. Via a multistage cluster randomized sampling method, 2123 adults aged between 30 and 75 years who had no history of cardiovascular diseases were selected for the study.
Aim: To explore the association of visceral adipose tissue (VAT) area and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM).
Methods: This was a cross-sectional study comprising 100 patients with T2DM and 100 non-T2DM individuals, matched for age, sex, and body mass index (BMI). Transient elastography was used to assess hepatic steatosis and liver stiffness measurements (LSM).
Introduction: To evaluate the efficacy of empagliflozin compared to pioglitazone in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM).
Methods: In this prospective randomized, double-blind, placebo-controlled trial, we assigned 106 patients with NAFLD and T2DM to receive empagliflozin 10 mg (n = 35), pioglitazone 30 mg (n = 34), or placebo (n = 37) for 24 weeks. Liver fat content and liver stiffness were measured using fibroscans.