Publications by authors named "Mojtaba Karimipour"
Article Synopsis
- The article DOI: 10.1016/j.heliyon.2022.e10798 has some inaccuracies that need to be addressed.
- This correction aims to clarify and rectify those errors to enhance understanding.
- It emphasizes the importance of maintaining accuracy in academic publications for the benefit of researchers and readers alike.*
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a complex condition affecting hormones and metabolism, and the study investigates the impact of chlorogenic acid (CGA) on this disorder using a rat model.
- The experiment involved 18 rats divided into three groups: a control group, a PCOS group without treatment, and a PCOS group treated with CGA, with various hormonal and ovarian analyses conducted thereafter.
- Results showed that CGA treatment led to a significant decrease in certain hormones and cystic follicles while increasing the levels of others, suggesting CGA may beneficially influence follicular development and hormonal balance in PCOS-affected rats.
Article Synopsis
- - The study explored how chlorogenic acid (CGA) can protect mouse testicular tissue from damage caused by ionizing radiation (IR) during pelvic cancer treatment.
- - Seventy mice were used in an experiment where one group was exposed to IR alone, while others were treated with various doses of CGA after IR exposure, and their testes were analyzed later.
- - Results showed that CGA, especially at 40 mg/kg, significantly reduced damage to sperm production and improved various biochemical markers, indicating that higher doses of CGA have better protective and therapeutic effects.
Background: Chlorogenic acid (CGA) is one of the well-known polyphenol compounds possessing several important biological and therapeutic functions. In order to optimize a culture system to achieve complete development of follicles, we focused on the effects of CGA supplementation during in vitro culture (IVC) on follicular development, oxidative stress, antioxidant capacity, developmental gene expression, and functional potential in cultured mouse ovarian tissue.
Methods And Results: The collected whole murine ovaries were randomly divided into four groups: (1) non-cultured group (control 1) with 7-day-old mouse ovaries, (2) non-cultured group (control 2) with 14-day-old mouse ovaries, (3) cultured group (experimental 1) with the culture plates containing only the basic culture medium, (4) cultured group (experimental 2) with the culture plates containing basic culture medium + CGA (50, 100 and 200 µmol/L CGA).
Article Synopsis
- Skin flap necrosis poses a significant challenge in plastic surgeries, prompting research into potential treatments.
- In a study with rats, three groups were given different doses of metformin after surgery to create a dorsal skin flap, with results showing improved survival rates in those treated with metformin.
- The low dose of metformin not only increased skin flap survival but also enhanced blood vessel density and the expression of vascular endothelial growth factor (VEGF) in the tissues, indicating better healing.
Background: Oxidative stress is a major contributor to diabetes, which can lead to testicular damage and infertility.
Objective: This study aimed to compare the effects of metformin as a chemical drug with silymarin as an herbal agent on the sperm parameters and histopathological changes of testes in diabetic rats.
Materials And Methods: Thirty-two male Wistar rats (250-270 gr) were randomly divided into four groups: 1) control; 2) diabetic; 3) diabetic+metformin 200 mg/kg; and 4) diabetic+silymarin 100 mg/kg.
Background: Cerium oxide nanoparticles (CeO NPs) as an important nanomaterial have a wide range of applications in many fields and human beings' exposure to this nanomaterial is unavoidable. The effects of CeO NPs on the male reproductive system are controversial.
Objective: To determine the effects of the administration of CeO NPs on the testis tissue, sperm parameters, and in vitro fertilization (IVF) in mice.
Background: This study investigated the potential effects of Titanium dioxide nanoparticles (Tio2NPs) followed by maternal gavage on fetal development and neural tube formation during pregnancy in mice.
Methods: Thirty pregnant mice were randomly divided into five main study groups including the untreated control and 4 experimental groups (n=6 per group). The control group was treated with normal saline and the experimental groups were orally treated with doses of 30, 150, 300, and 500 Body Weight (BW) of Tio2NPs during pregnancy.
Aim: To investigate the effect of Propolis-gum Arabic as a nerve guidance channel.
Material And Methods: Male rats (n=24) were randomly divided into sham surgery, autograft, and Propolis+gum Arabic groups with equal numbers. Under anesthesia, the sciatic nerve was removed, and the gap between the two ending was repaired by Propolis-gum Arabic or nerve autograft.
Titanium dioxide particles (TiO) as the second most widely used materials in consumer products are composed of nano-sized (<100 nm) particles (NPs) and fine-sized (>100 nm) particles (FPs). Toxicological studies on animals have shown that TiO NPs exposure can cross the blood-testis barrier and accumulate in the testis resulting in testicular tissue damage and reduction of sperm count and motility. However, there is no information on the toxic effects of TiO FPs on male reproductive fertility.
View Article and Find Full Text PDFBackground: The production of stress oxidative condition in body which is caused by consumption of ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) leads to a liver damage. As an antioxidant, Vitamin E can protect cells and tissues against the deleterious effects of free radicals. This study evaluates the protective effects of Vitamin E on MDMA induced liver toxicity.
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- The study investigates the effects of long-term exposure to low doses of pesticide mixtures on rats, assessing changes in behavior, brain structure, and function.
- Male Wistar rats were exposed for 90 days to different doses of a mixture of five pesticides, revealing that higher doses caused significant harmful effects on the nervous system.
- Even at the legally permitted levels, medium doses led to oxidative stress and memory impairment, indicating that pesticide mixtures can be harmful in ways not currently understood.
Fluoxetine is a selective serotonin reuptake inhibitor is commonly prescribed to treat maternal depression in pregnancy and lactation. This study aimed to investigate the effects of maternal exposure to fluoxetine via lactation on testicular tissue, sperm parameters including count, motility, viability, and normal morphology and testicular oxidative stress status in male mice offspring. Ten mice dams were divided into control and experimental groups.
View Article and Find Full Text PDFIn this study, we investigated the potential of thymol and its mode of action to protect against the titanium dioxide (TiO) nanoparticle-induced testicular damage. Twenty-four rats were randomly divided into four groups: control group, TiO (100 mg/kg BW/day) group, TiO + thymol (10 mg/kg BW/day) group, and TiO + thymol (30 mg/kg BW/day) group. With the exception of the control group, all animals received orally TiO nanoparticles for 60 days.
View Article and Find Full Text PDFPrevious studies proved the pro-angiogenic effect of Crocetin, a natural carotenoid dicarboxylic acid, in both and models. However, the exact mechanism of Crocetin action has not completely been elucidated yet. The current experiment was designed to find the activity of PI3K-Akt-eNOS axis after the treatment of endothelial cells with Crocetin .
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- This study aimed to assess the impact of various remote ischemic preconditioning (RIPC) techniques on spinal cord injury caused by ischemia-reperfusion in rats.
- A total of 36 rats were divided into six groups, and different RIPC methods were applied before inducing spinal cord ischemia, with evaluations conducted 72 hours post-injury to measure neurological function and tissue damage.
- The findings indicated that RIPC methods involving both hind and/or fore limbs improved motor function, reduced oxidative stress markers, and minimized white matter damage compared to the control group, suggesting these techniques offer protective benefits against spinal cord ischemic injuries.
Background: Phenylhydrazine (PHZ) induced anemia and was shown to have harmful effects on the male reproductive system.
Objective: To investigate the protective effect of vitamin C (Vit C) on sperm parameters quality, in vitro fertilization potential and embryonic development in a mouse model of hemolytic anemia induced by PHZ.
Materials And Methods: Thirty-two NMRI adult male mice ( = 8/each) were randomly classified into four groups.
Objectives: Paraplegia is deterioration in motor or sensory function of the lower limbs that can occur after modification of a thoracoabdominal aortic aneurysm. The purpose of this survey was to determine the protective action of lutein on spinal cord ischemia-reperfusion (I-R) damage.
Materials And Methods: Thirty-five male rats were distributed into five groups: intact, sham, dimethyl sulfoxide (I-R+DMSO), low dose lutein (I-R+0.
Previous studies have identified the heart as a source and a target tissue for oxytocin and relaxin hormones. These hormones play important roles in the regulation of cardiovascular function and repair of ischemic heart injury. In the current study, we examined the impact of oxytocin and relaxin on the development of cardiomyocytes from mesenchymal stem cells.
View Article and Find Full Text PDFObjectives: Skin flap necrosis is the most common postoperative side effect in reconstructive surgeries. Glutamine (GLN) has been shown to accelerate wound healing process. The purpose of this study was to evaluate the effects of GLN either in free form or in the dipeptide form along with L- alanyl (Ala-GLN) on random skin flaps survival in rats.
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- Titanium dioxide nanoparticles (TiONP) are found in products like food, cosmetics, and drugs but may negatively affect female reproductive systems, particularly fertility.
- A study on female mice showed that those given oral TiONP experienced harmful changes in ovarian structure and reduced pregnancy rates compared to a control group.
- The results indicated that TiONP exposure led to decreased oocyte numbers, lower fertilization rates, and hormonal imbalances, suggesting significant fertility issues in affected mice.
Article Synopsis
- The study examines the protective effects of spinach extract against spinal ischemia/reperfusion injury, which can lead to paraplegia or paraparesis after thoraco-abdominal aorta surgery.
- Thirty-five male Sprague-Dawley rats were divided into groups to assess neurological function and biochemical markers 72 hours post-ischemia.
- Results showed that rats treated with spinach extract had better motor function, higher antioxidative capacity, and preserved motor neurons compared to the normal saline control group.
Objective: To explore the effects of pre post ischemic treatment with metformin after global cerebral ischemia in rats.
Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min. Metformin (200 mg/kg) or vehicle was given orally by gavage for 7-14 days.
Objectives: When the nerve is injured near its entrance to the muscle belly, we cannot perform conventional methods. One useful method in such a situation is neurotization surgery. In this study, Bone marrow mesenchymal stem cells (BMSCs) implanted into the paralyzed muscle after neurotization surgery.
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