Naloxone could limit morphine hypersensitivity: Considering the molecular mechanisms.

Background: Naloxone has been used as an opioid antagonist to prevent multiple adverse side effects of opioid-like tolerance and hyperalgesia. This study has investigated naloxone combined with morphine to limit pain hypersensitivity. In addition, the expression of brain-derived neurotrophic factor (BDNF) and K Cl cotransporter2 (KCC2) were also studied.