Publications by authors named "Mojca Stampar"
Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of recurrent driver mutations in many pediatric brain tumors. However, despite these molecular advances, the clinical outcomes of high grade tumors, including H3K27M diffuse midline glioma (H3K27M DMG), remain poor.
View Article and Find Full Text PDFGenomic characterization has begun to redefine diagnostic classifications of cancers. However, it remains a challenge to infer disease phenotypes from genomic alterations alone. To help realize the promise of genomics, we have performed a quantitative proteomics investigation using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and 41 tissue samples spanning the 4 genomically based subgroups of medulloblastoma and control cerebellum.
View Article and Find Full Text PDFArticle Synopsis
- * In experiments with female mice, exposure to scents from mature male bedding influenced the development of new neurons in a key brain area (the accessory olfactory bulb) after puberty, while scents from younger males did not have the same effect.
- * The increase in new neuron activity in response to male odors suggests a connection between sensory experiences and brain changes, allowing female mice to distinguish between individual male scents only after reaching puberty.
Vamorolone, a dissociative steroidal compound, reduces pro-inflammatory cytokine expression in glioma cells and increases activity and survival in a murine model of cortical tumor.
Oncotarget
February 2017
Article Synopsis
- Corticosteroids like dexamethasone are commonly used in neuro-oncology for their anti-inflammatory effects, but many patients suffer from negative side effects.
- This study explored vamorolone, a new steroid alternative, in a mouse model to see if it could reduce harmful side effects while maintaining anti-inflammatory benefits.
- Results showed that vamorolone effectively reduced pro-inflammatory signals like dexamethasone, but had a better safety profile, improving activity and survival in mice compared to those treated with dexamethasone.