Classifying schizophrenia using functional MRI and investigating underlying functional phenomena.

Background: Existing studies have revealed functional abnormalities in certain brain regions of patients with schizophrenia (SZ), but the relationships between these abnormalities and their impact on disease progression remain unclear.

Methods: Fifty-six patients with SZ and 56 healthy controls were included. Based on resting-state functional magnetic resonance imaging, we analyzed fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), and degree centrality (DC).