Publications by authors named "Moira Differding"
Article Synopsis
- The study investigates the link between plastic bottle feeding and various health indicators in infants during their first year of life.
- It involved 442 infants from the Nurture birth cohort, analyzing the impact of plastic bottle feeding frequency at 3 months on growth metrics and microbiota composition at 12 months.
- Results showed that while plastic bottle feeding frequency affected fecal microbiota diversity and specific short-chain fatty acid levels, it did not lead to significant differences in overall growth measures, except for a slight impact on length-for-age.
Pre-pregnancy body mass index and gut microbiota of mothers and children 5 years postpartum.
Int J Obes (Lond)
September 2023
Background: Maternal pre-pregnancy body mass index (BMI) has been linked to altered gut microbiota in women shortly after delivery and in their offspring in the first few years of life. But little is known about how long these differences persist.
Methods: We followed 180 mothers and children from pregnancy until 5-year postpartum in the Gen3G cohort (Canada, enrolled 2010-2013).
Article Synopsis
- Elective, prelabor C-sections limit newborn exposure to beneficial vaginal microbiota, potentially leading to differences in microbiota development and increased risks of immune and metabolic diseases.
- A clinical trial compared vaginal seeding (applying maternal vaginal fluids to C-section newborns) against a placebo to see its effects on the microbiota in neonates.
- Results showed that vaginal seeding improved transfer of maternal microbes and changed the composition of skin and stool microbiota, highlighting the need for further research to explore its long-term impacts.
Objective: The aim of this study was to examine associations of gut microbiome diversity and composition with directly measured regional fat distribution, including central fat, in a large community-based cohort.
Methods: A cross-sectional investigation was conducted in the Baltimore Longitudinal Study of Aging (N = 815, 55.2% female, 65.
Article Synopsis
- This study explores the effects of plastic bottle feeding on the gut microbiota and growth of infants in their first year of life, revealing significant associations.
- Infants fed with plastic bottles less frequently showed lower diversity in fecal microbiota and reduced levels of propionic acid, both at three months.
- Additionally, less frequent bottle use negatively affected the length-for-age growth metric by 12 months, suggesting that plastic bottle exposure could influence both microbiome development and overall growth in infants.
Objective: To determine the longer-term effects of metformin treatment and behavioral weight loss on gut microbiota and short-chain fatty acids (SCFAs).
Research Design And Methods: We conducted a 3-parallel-arm, randomized trial. We enrolled overweight/obese adults who had been treated for solid tumors but had no ongoing cancer treatment and randomized them ( = 121) to either ) metformin (up to 2,000 mg), ) coach-directed behavioral weight loss, or ) self-directed care (control) for 12 months.
Human milk harbors its own microbiota, but whether the microbes seed the infant gut and are modified by breastfeeding practices is unresolved. In this issue, Fehr et al. (2020) sequence breastmilk and infant stool samples from mother-infant dyads to investigate the co-occurrence of milk-gut bacteria and the impact of breastfeeding practices.
View Article and Find Full Text PDFBackground: Introducing complementary foods other than breastmilk or formula acutely changes the infant gut microbiota composition. However, it is unknown whether the timing of introduction to complementary foods (early vs. late) in infancy is associated with early childhood gut microbiota and BMI, and if these associations depend on breastfeeding duration.
View Article and Find Full Text PDFBackground: Early introduction of complementary foods has been associated with various immune disorders, oxidative stress, and obesity in childhood. The gut microbiota and the short chain fatty acids (SCFAs) they produce are postulated to be on the causal pathway. The objective of this study was to determine if early complementary feeding (i.
View Article and Find Full Text PDFAssociation of prenatal antibiotics with measures of infant adiposity and the gut microbiome.
Ann Clin Microbiol Antimicrob
June 2019
Background: Prenatal antibiotic exposure has been associated with an altered infant gut microbiome composition and higher risk of childhood obesity, but no studies have examined if prenatal antibiotics simultaneously alter the gut microbiome and adiposity in infants.
Method: In this prospective study (Nurture: recruitment 2013-2015 in North Carolina, United States), we examined in 454 infants the association of prenatal antibiotic exposure (by any prenatal antibiotic exposure; by trimester of pregnancy; by number of courses; by type of antibiotics) with infant age- and sex-specific weight-for-length z score (WFL-z) and skinfold thicknesses (subscapular, triceps, abdominal) at 12 months of age. In a subsample, we also examined whether prenatal antibiotic exposure was associated with alterations in the infant gut microbiome at ages 3 and 12 months.