Publications by authors named "Moira Brennan"
Simple and effective bacterial-based intratumoral cancer immunotherapy.
J Immunother Cancer
September 2021
Article Synopsis
- Researchers tested a slow-release emulsion of killed mycobacteria (CFA) for treating tumors in mice, dogs, horses, and human cancer patients, analyzing its effects on survival and immune response.
- * In preclinical trials, significant tumor regression and extended survival were observed across all species, with immune cell analysis indicating that early neutrophil infiltration predicted treatment success.
- * The treatment was well tolerated in human patients, and CT scans showed tumor regression, particularly in a late-stage renal cancer patient.
Approximately 7% of old, unthrifty sheep (Ovis aries) in New Zealand have intestinal adenocarcinomas. To investigate whether these sheep might be used as a model of human colonic neoplasia, the biologic behavior and histologic appearance of ovine intestinal adenocarcinomas were compared with those reported for human colonic adenocarcinomas. We collected 50 intestinal tracts with grossly visible intestinal neoplasia from slaughtered sheep.
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