Neoteric Predictors for Lymph Node Metastasis in Early Oral Squamous Cell Carcinoma: Tumor Budding and Worst Pattern of Invasion.

Oral cancer is one of the most common cancers seen in the Indian subcontinent. Its primary treatment is surgery with or without adjuvant treatment. Despite advances in science, prognosis and overall survival has not yet chanced over the past two decades.

Fire safety status and evacuation of medical facility considering elevated oxygen concentrations.

The prevalence of infectious diseases and rapid population expansion has increased the number of medical facilities. Due to the patients' limited mobility, these hospitals are more susceptible to fire disasters. Both Pathfinder and Fire Dynamic simulators were used to calculate the required safe evacuation time (RSET), heat release rate, visibility, temperature, CO, and oxygen effects on temperature, and available safe evacuation time (ASET).

Hospital pharmacists', doctors' and nurses' perceptions of intra- and inter- professional communication in the context of electronic prescribing and medication administration systems: A qualitative study.

Background: Effective, integrated and coordinated communication is essential in providing high quality patient care. Little prior research has detailed the impact of electronic prescribing and medication administration (ePMA) systems on healthcare professionals' (HCPs') communication. We investigated hospital pharmacists', doctors' and nurses' perceptions of how ePMA systems have affected, or are expected to affect, the way they communicate with each other in an inpatient setting.

The Submental Flap for Reconstruction of Tongue Defects- Surgical Outcome and Quality of Life Assessment.

Unlabelled: Tongue defects following resection of cancers, have a major effect on speech and swallowing, impairing the quality of life. Free flaps such as the free radial artery forearm flap and anterolateral thigh flap have been ideal for the reconstruction of such defects depending upon the volume of tissue loss. Local flaps such as the submental flap and pectoralis major myocutaneous flap serve as an alternative in decreasing morbidity and improving functional outcomes.

Smartphone Recordings are Comparable to "Gold Standard" Recordings for Acoustic Measurements of Voice.

Purpose: The purpose of this study was to assess the relationship and comparability of cepstral and spectral measures of voice obtained from a high-cost "flat" microphone and precision sound level meter (SLM) vs. high-end and entry level models of commonly and currently used smartphones (iPhone i12 and iSE; Samsung s21 and s9 smartphones). Device comparisons were also conducted in different settings (sound-treated booth vs.

Submental Flap in the Reconstruction of Palatal Defects.

Amongst oral cancers, malignancies of the palate and the upper gingivo-buccal complex are relatively uncommon. Following resection, defects in the palate lead to a nasal speech and nasal regurgitation on swallowing. This is best overcome with a prosthetic obturator which occludes the palatal defect and has dentures for the upper alveolus.

Do digital impressions have a greater accuracy for full-arch implant-supported reconstructions compared to conventional impressions? An study.

Aim: The purpose of this study was to compare the accuracy of conventional implant impressions with digital impression techniques made using two different intraoral scanners.

Setting And Design: In-Vitro study.

Material And Methods: A scan of master cast containing four implants was made using two intraoral scanners: CEREC Primescan (Dentsply Sirona, USA) and 3Shape Trios (Copenhagen, Denmark) with PEEK scan bodies attached to the implants.

Effects of surface modification techniques on zirconia substrates and their effect on bonding to dual cure resin cement - An study.

Aim: This study aims to evaluate the effect of different surface treatments of monolithic zirconia on the bond strength of resin to zirconia and, to explore alternative methods to improve this bonding.

Settings And Design: In-Vitro study.

Materials And Methods: Fifty rectangular sintered blocks of Yttria-stabilized Tetragonal Zirconia Polycrystal ceramics of dimensions were milled and sintered.

Open-source electronic health record systems: A systematic review of most recent advances.

Open-source Electronic Health Records (OS-EHRs) are of pivotal importance in the management, operations, and administration of any healthcare organization. With the advancement of health informatics, researchers and healthcare practitioners have proposed various frameworks to assess the maturation of Open-source EHRs. The significance of OS-EHRs stems from the fact that vendor-based EHR implementations are becoming financially burdensome, with some vendors raking in more than $1 billion with one contract.

The Effect of Microphone Frequency Response on Spectral and Cepstral Measures of Voice: An Examination of Low-Cost Electret Headset Microphones.

Purpose: The purpose of this study was to establish the frequency response of a selection of low-cost headset microphones that could be given to subjects for remote voice recordings and to examine the effect of microphone type and frequency response on key acoustic measures related to voice quality obtained from speech and vowel samples.

Method: The frequency responses of three low-cost headset microphones were evaluated using pink noise generated via a head-and-torso model. Each of the headset microphones was then used to record a series of speech and vowel samples prerecorded from 24 speakers who represented a diversity of sex, age, fundamental frequency ( ), and voice quality types.

Controlled (re)evaluation of the relationship between speech perception in noise and contralateral suppression of otoacoustic emissions.

In people with normal hearing (NH), speech perception in noise (SPIN) improves when the speech signal is presented not gated with noise but after a delay. The medial olivocochlear reflex (MOCR) was thought to be involved in the neural dynamic range adaptation (NDRA) responsible for this adaptive SPIN; however, some of the recent studies do not support this hypothesis and suggest that adaptive SPIN involves the NDRA to noise-level statistics, irrespective of MOCR activation. A plausible reason for this discrepancy could be the variations and limitations of the experimental designs used in different studies.

A Comparison of Conventional Intravitreal Injection Method vs InVitria Intravitreal Injection Method.

Purpose: To compare use of the conventional intravitreal injection method to the InVitria intravitreal injection device. Three outcome measures were studied: patient comfort, speed of injection and cost-effectiveness.

Patients And Methods: A prospective review of 58 patients was undertaken.

Submental flap: Game changer in oral cancer reconstruction-A study of 1169 cases.

Background: Free-flap reconstructions (FFRs) are the standard-of-care following resections for oral cancer. This study assessed an alternative, the pedicled submental flap (SF) for its versatility, oncological outcomes, and comparative operative time and cost.

Methods: This was a longitudinal prospective study of 1169 patients of oral cancer reconstructed with the SF.

Skin lesion classification using ensembles of multi-resolution EfficientNets with meta data.

In this paper, we describe our method for the ISIC 2019 Skin Lesion Classification Challenge. The challenge comes with two tasks. For task 1, skin lesions have to be classified based on dermoscopic images.

Comparison of Questionnaire-Based and Performance-Based Screening Tools as Predictors of Auditory Processing Disorder.

Purpose The purpose of this study was to compare questionnaire-based and performance-based screening tools as predictors of an auditory processing disorder (APD) diagnosis. The questionnaire-based screening tools used were the Children's Auditory Performance Scale, Fisher's Auditory Problems Checklist, and Buffalo Model Questionnaire-Revised. The performance-based screening tools were from the SCAN-3 screening tests, that is, Auditory Figure Ground, Competing Words Free Recall (CW-FR), and Gap Detection Test.

The impact of electronic prescribing systems on healthcare professionals' working practices in the hospital setting: a systematic review and narrative synthesis.

Background: The aim of this systematic review was to synthesise peer-reviewed literature assessing the impact of electronic prescribing (eP) systems on the working practices of healthcare professionals (HCPs) in the inpatient setting and identify implications for practice and research.

Methods: We searched PubMed, Medline, Embase, Cochrane and the Cumulative Index to Nursing Allied Health Literature databases for studies published from inception to November 2018. We included controlled, uncontrolled, observational and descriptive studies that explored the effect of eP on HCPs' working practices in an inpatient setting.

Hearing and Balance Disorders in the State of Hawai'i: Demographics and Demand for Services.

Hearing and balance disorders affect people of all ages. Among children, hearing loss affects speech and language development, academic performance, and psychosocial development. Hearing loss in adults negatively impacts work productivity, cognitive function, and psychosocial status.

Maturational Changes in Ear Advantage for Monaural Word Recognition in Noise Among Listeners with Central Auditory Processing Disorders.

This study aimed to investigate differences between ears in performance on a monaural word recognition in noise test among individuals across a broad range of ages assessed for (C)APD. Word recognition scores in quiet and in speech noise were collected retrospectively from the medical files of 107 individuals between the ages of 7 and 30 years who were diagnosed with (C)APD. No ear advantage was found on the word recognition in noise task in groups less than ten years.

Impact of Different Cutoff Criteria on Rate of (Central) Auditory Processing Disorders Diagnosis Using the Central Test Battery.

The purpose of this study was to quantify how the use of two different cutoff criteria affects the test failure rate and potential diagnosis of central auditory processing disorder ([C]APD) in a sample of children subjected to central auditory processing ([C]AP) assessment. Test failure rates for the central test battery (CTB) using two different cutoff criteria (1 and 2 SDs below the mean) were measured retrospectively for 98 children who completed (C)AP assessment. The rates of potential (C)APD diagnosis ranged from 86.

AN AUDIT OF PAEDIATRIC VANCOMYCIN DOSING.

Aim: To audit whether a new paediatric vancomycin guideline is being adhered to and if therapeutic levels are being achieved.

Method: Data on doses, age, weight, vancomycin levels, time taken and renal function were collected prospectively by reviewing drug charts of paediatric patients on vancomycin. The patients were followed for their whole vancomycin journey in order to observe if the guidelines were followed throughout.

In Vitro and In Vivo Assessment of Docetaxel Formulation Developed for Esophageal Stents.

Esophageal cancer (EC) mostly affects the elderly population and is frequently diagnosed at an advanced stage. Self-expanding metal stents (SEMS) are the most popular mode of palliation, but they are associated with reocclusion caused by tumor growth. To overcome this problem, docetaxel (DTX)-loaded polyurethane formulations were prepared for stent application.

Effect of polymer microstructure on the docetaxel release and stability of polyurethane formulation.

PurSil®AL20 (PUS), a copolymer of 4,4'-dicyclohexylmethane diisocyanate (HMDI), 1,4-butane diol (BD), poly-tetramethylene oxide (PTMO) and poly-dimethyl siloxane (PDMS) was investigated for stability as a vehicle for Docetaxel (DTX) delivery through oesophageal drug eluting stent (DES). On exposure to stability test conditions, it was found that DTX release rate declined at 4 and 40 °C. In order to divulge reasons underlying this, changes in DTX solid state as well as PUS microstructure were followed.

Engineering Stent Based Delivery System for Esophageal Cancer Using Docetaxel.

Esophageal cancer patients are often diagnosed as "advanced" cases. These patients are subjected to palliative stenting using self-expanding metallic stents (SEMS) to maintain oral alimentation. Unfortunately, SEMS get reoccluded due to tumor growth, in and over the stent struts.

Enhancement of docetaxel solubility using binary and ternary solid dispersion systems.

Context: Poor biopharmaceutical properties and toxicities associated with the intravenous formulation of docetaxel (DTX) necessitate the exploration of an alternate oral route of delivery.

Objective: This study aims at enhancing the solubility of poorly soluble drug, DTX with the help of solid dispersion (SD) technique.

Method: DTX SDs were formulated with selected solubilizers, including Kollidon 12PF, Lutrol F68, Soluplus and Hydroxypropyl-β-cyclodextrin in different weight ratios.

Patient involvement in medication safety in hospital: an exploratory study.

Background: Medication errors are common in hospital inpatients. While many interventions have been proposed to address these problems, few have been shown to have significant benefits. A complementary approach is to facilitate greater involvement of patients with their inpatient medication.