Aminoquinoline-Based Tridentate ()-Copper Catalyst for C-N Bond-Forming Reactions from Aniline and Diazo Compounds.

A new tridentate Cu complex based on ()-1-(pyridin-2-yl)--(quinolin-8-yl)methanimine (PQM) was generated and characterized to support the activation of diazo compounds for the formation of new C-N bonds. This neutral Schiff base ligand was structurally characterized to coordinate with copper(II) in an equatorial fashion, yielding a distorted octahedral complex. Upon characterization, this copper(II) complex was used to catalyze an efficient and cost-effective protocol for C-N bond formation between -nucleophiles and copper carbene complexes arising from the activation of diazo carbonyl compounds.

Copper complexes for the chemoselective -arylation of arylamines and sulfanilamides Chan-Evans-Lam cross-coupling.

Copper(II) complexes with tridentate -ligands were utilized for Chan-Evans-Lam (CEL) cross-coupling reactions to enable the -arylation of multifarious -nucleophiles through the activation of aryl boronic acids. A condition-specific methodology was developed to chemoselectively target the amine sulfonamide -arylation of 4-aminobenzenesulfonamide using new catalysts. Two different pyridine-based ligands and corresponding copper(II) complexes were characterized using H and C-NMR, FTIR, and UV-vis spectroscopy, HRMS, single-crystal X-ray diffraction, and cyclic voltammetry.

Sodium Trifluoroacetate mediated Copper-Catalyzed -Michael addition of -unsaturated olefins with aromatic amines.

We present a sodium trifluoroacetate (CFCONa) mediated copper-catalyzed -Michael addition of aromatic amines with activated olefins under mild, aqueous reaction conditions. This simplistic protocol employs a copper catalyst (10 mol%) and water as solvent. This transformation occurs precisely with aromatic substituted amines containing both electron-donating (EDG) and electron-withdrawing (EWG) groups.

Graphene oxide-cationic polymer conjugates: Synthesis and application as gene delivery vectors.

Nanomedicine as the interface between nanotechnology and medical sciences is a new area that has attracted the attention of vast groups of researchers. Carbon nanomaterials are common platform for synthesis of nanoparticles for biomedical applications due to their low cytotoxicity and feasible internalization into mammalian cell lines (Yang et al., 2007; Arora et al.