Publications by authors named "Mohsen Gozari"
Article Synopsis
- The study examined how different temperatures (22°C, 25°C, 27°C, and 29°C) affect Vibrio populations and heat shock protein (HSP) gene expression (HSP 90, HSP 70, HSP 20) in rayed pearl oysters.
- Five dominant Vibrio strains were identified, with the highest populations found at 29°C, particularly V. parahaemolyticus, V. alginolyticus, and V. harveyi.
- HSP gene expression varied by tissue and temperature; HSP20 increased at higher temperatures in the gonad and mantle, while HSP90 decreased, providing insights into how these oysters adapt to thermal stress.
The marine ecosystem has been known to be a significant source of novel enzymes. Esterase enzymes (EC 3.1.
View Article and Find Full Text PDFMarine organisms are rich sources of enzymes and their inhibitors having enormous therapeutic potential. Among different proteolytic enzymes, serine proteases, which can be obtained from various marine organisms show a potential to biomedical application as thrombolytic agents. Although this type of proteases plays a crucial role in almost all biological processes, their uncontrolled activity often leads to several diseases.
View Article and Find Full Text PDFThe marine environment with its vast biological diversity encompasses many organisms that produce bioactive natural products. Marine microorganisms are rich sources of compounds from many structural classes with a multitude of biological activities. The biosynthesis of microbial natural products depends on a variety of biotic and abiotic factors in the marine environment, including temperature, nutrients, salinity and interaction with other microorganisms.
View Article and Find Full Text PDFWe isolated an actinobacterium, sp. strain SP 85 from the marine sponge Polyphasic identification of the microorganism showed that the strain SP 85 had high 16S rRNA gene similarity (99%) with strain NBRC 12805, while some physiological and biochemical differences were observed. A cytotoxic compound, was isolated from the active culture extract of the strain SP 85 by bioassay-guided purification over silica gel column chromatography, preparative TLC, and HPLC.
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- Preliminary analysis showed that Streptomycetaceae family dominated the samples, accounting for 66% of the isolates, while 23.8% of the isolates could inhibit the growth of specific test microbes, primarily from the same family.
- The top five isolates demonstrated significant cytotoxic effects on various tumor cell lines, with 97-99% genetic similarity to known Streptomyces species, suggesting their potential as sources for developing new antitumor antibiotics.