Analysing the surface morphology of annealed FTO/ZnS bilayer films: stereometric, fractal, and wettability approaches.

The surface micromorphology and roughening of the thermal evaporation-coated FTO/ZnS bilayer thin films annealed at 300, 400, 500, and for 1 h have been studied. AFM images of the prepared samples were analysed by the MountainsMap software, and the effects of the annealing temperature on the surface texture of the FTO/ZnS thin film's surface were investigated. Stereometric and advanced fractal analyses showed that the sample annealed at exhibited greater surface roughness and greater skewness and kurtosis.

A Molecular Thermodynamic Model of Coacervation in Solutions of Polycations and Oppositely Charged Micelles.

To guide the rational design of personal care formulations, we formulate a molecular thermodynamic model that predicts coacervation from cationic polymers and mixed micelles containing neutral and anionic surfactants and added salt. These coacervates, which form as a result of dilution of conditioning shampoos during use, deposit conditioning agents and other actives to the scalp or skin and also provide lubrication benefits. Our model accounts for mixing entropy, hydrophobic interactions of polycation with water, free energies of bindings of oppositely charged groups to micelles and polycations, and electrostatic interactions that capture connectivity of charged groups on the polycation chain and the micelle.

Feasibility study of detecting some milk adulterations using a LED-based Vis-SWNIR photoacoustic spectroscopy system.

The aim of this study is to evaluate a previousely developed photoacoustic spectroscopy system with light sources of visible to short-wave near infrared (Vis-SWNIR, 395-940 nm) for detection of adulterations in cow's milk including formalin, urea, hydrogen peroxide, starch, sodium hypochlorite, and detergent powder. The results of principal component analysis (PCA) showed a very good visual differentiation of different adulterations. The artificial neural networks (ANN) showed the highest classification accuracy (97.

Effect of deficit irrigation on physiological, biochemical, and yield characteristics in three baby corn cultivars (Zea mays L.).

The main problem in the production of crops in arid and semi-arid regions of the world is the lack of water and its effect on the plant in the form of drought stress. Cultivation of key crops such as corn, which also requires a lot of water, is not possible in these areas except by applying water consumption management methods. Among the most important of these methods is deficit irrigation.

A multi-objective optimization using response surface model coupled with particle swarm algorithm on FSW process parameters.

In this study, multi-objective optimization of mechanical properties in friction-stir-welding of AH12 1050 aluminum alloy is performed using a combination of the response surface method and multi-objective particle swarm optimization algorithm. The process parameters are considered as tool pin diameter, shoulder diameter, rotational speed, feed speed, and tool tilt angle. The heat-affected zone's yield strength, fracture strain, impact toughness, and hardness on the advancing and retreating sides are selected as the objective functions.

Geogenic and anthropogenic sources identification and ecological risk assessment of heavy metals in the urban soil of Yazd, central Iran.

Urban soil pollution with heavy metals is one of the environmental problems in recent years, especially in industrial cities. The aim of this study is to evaluate the role of geogenic and anthropogenic sources in the urban soil pollution in Yazd, Iran. For this purpose, 30 top-soil (0-10 cm) samples from Yazd within an area of 136.

Extracting free energies of counterion binding to polyelectrolytes by molecular dynamics simulations.

We use all-atom molecular dynamics simulations to extract ΔG, the free energy of binding of potassium ions K to the partially charged polyelectrolyte poly(acrylic acid), or PAA, in dilute regimes. Upon increasing the charge fraction of PAA, the chains adopt more extended conformations, and simultaneously, potassium ions bind more strongly (i.e.

In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies.

The complexity and heterogeneity of the three-dimensional (3D) tumor microenvironment have brought challenges to tumor studies and cancer treatment. The complex functions and interactions of cells involved in tumor microenvironment have led to various multidrug resistance (MDR) and raised challenges for cancer treatment. Traditional tumor models are limited in their ability to simulate the resistance mechanisms and not conducive to the discovery of multidrug resistance and delivery processes.

Predictive Biomarker Panel in Proliferative Lupus Nephritis- Two-Dimensional Shotgun Proteomics.

Introduction: Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematous (SLE). With no specific clinical or laboratory manifestation to predict response to treatment, this study was aimed to provide a panel of predictive biomarkers of response before initiation of treatment.

Methods: Liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis was performed on plasma and urine samples of 11 patients with biopsy proven proliferative LN at the time of biopsy.

Pollution, human health risk assessment and spatial distribution of toxic metals in urban soil of Yazd City, Iran.

Heavy metal pollution significantly reduces the quality of the environment and threatens human health, especially in industrial cities. This study investigated toxic metals concentrations, pollution levels and human health risks assessment of urban soils in Yazd City, as an industrial city in center of Iran. Soil surface samples (0-10 cm) were collected from 30 points in the area for geochemical analysis.

Overcharging of polyelectrolyte complexes: an entropic phenomenon.

Overcharging in complex coacervation, in which a polyelectrolyte complex coacervate (PEC) initially containing equal moles of the cationic and anionic monomers absorbs a large excess of one type of polyelectrolyte species, is predicted using a recently developed thermodynamic model describing complexation through a combination of reversible ion binding on the chains and long-range electrostatic correlations. We show that overcharging is favored roughly equally by the translational entropy of released counterions and the binding entropy of polyelectrolytes in the polyelectrolyte complex, thus helping resolve competing explanations for overcharging in the literature. We find that the extent of overcharging is non-monotonic in the concentration of added salt and increases with both strength of ion-pairing between polyions and chain hydrophobicity.

Epigenetic regulation and transcriptional memory in development; selection facilitating prudence.

The epigenetic mechanisms regulating developmental gene expression are examples of a strategy to generate unique expression profiles with global regulators controlling several genes. In a simplified view, a common set of tools, that include DNA motif recognizing proteins (recruiters), binding/interacting surfaces (ARPs- actin related proteins), epigenetic writers (histone methyltransferases, acetylases), readers (chromatin remodeling proteins, PRC1 members) and erasers (demethylases, deacetylases) form complexes which not only regulate transcription, but also retain the transcriptional memory through mitosis. There are two arms of epigenetic regulation: covalent modification of DNA and the post-translational modification of histones.

Quantitative Assessment of Thermodynamic Theory in Elucidating the Behavior of Water under Hydrophobic Confinement.

A macroscopic thermodynamics-based theory that can quantitatively describe the behavior of water confined between hydrophobic solutes has so far remained elusive. In this work, we progress toward this goal by comparing the predictions of macroscopic theory with the results from computer simulations. We have determined free energy profiles of water confined between two nanometer-sized surfaces of varying hydrophobicity using molecular simulations and have estimated thermodynamic properties such as contact angle, line tension, and size of the critical vapor tube from independent simulations.

Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression.

The Polycomb/Trithorax Responsive Elements (PRE/TREs) are the cis-regulatory sequences that interact with both repressive (PcG) as well as activating (TrxG) complexes. However, most of the mammalian PREs are demonstrated to interact with the repressive polycomb (PcG) complexes only. We have carried out an unbiased search for proteins interacting with human PRE-PIK3C2B (hPRE-PIK3C2B) based on DNA affinity purification followed by mass spectrometry and identified MLL, MLL4 and WDR87 among other proteins in three biological replicates in HEK, U87 and HeLa cell lines.

Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats.

Background: Diabetes mellitus is a chronic disease which may be accompanied by cognitive impairments. The expression of the obesity gene (ob) is decreased in insulin-deficient diabetic animals and increased after the administration of insulin or leptin. Plasma leptin levels are reduced in the streptozotocin (STZ)-induced diabetic rats.

Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats.

Objectives: Leptin exerts various effects on appetite and body weight. Disruption of the obesity gene is precedent to fatness. Insulin or glucose elevates leptin, but streptozotocin reduces it.

The functional diversity of Drosophila Ino80 in development.

Ino80 is well known as a chromatin remodeling protein with the catalytic function of DNA dependent ATPase and is highly conserved across phyla. Ino80 in human and Drosophila is known to form the Ino80 complex in association with the DNA binding protein Ying-Yang 1 (YY1)/Pleiohomeotic (Pho) the Drosophila homologue. We have earlier reported that Ino80 sub-family of proteins has two functional domains, namely, the DNA dependent ATPase and the DNA binding domain.

Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome.

Epigenetic cellular memory mechanisms that involve polycomb and trithorax group of proteins are well conserved across metazoans. The cis-acting elements interacting with these proteins, however, are poorly understood in mammals. In a directed search we identified a potential polycomb responsive element with 25 repeats of YY1 binding motifthatwe designate PRE-PIK3C2B as it occurs in the first intron of human PIK3C2B gene.

Efficacy of memoral herbal on prevention of electroconvulsive therapy-induced memory impairment in mood disorder patients (isfahan - iran 2011).

Background: Electroconvulsive therapy (ECT) is one of the most efficacious treatment for major depressive disorder (MDD), it is also used as a rapid and efficacious treatment for other psychiatric disorders, especially treatment resistant ones. The cognitive impairment is one of the most important side effects of ECT. This study examined the Memoral herbal efficacy in prevention of ECT-induced memory impairment.