Frequency and Geographic Distribution of Mutations in Patients With Severe Fungal Infections.

Autosomal recessive deficiency in the caspase recruitment domain containing protein 9 (CARD9) results in susceptibility to fungal infections. In the last decade, infections associated with CARD9 deficiency are more reported due to the advent of genome sequencing. The aim of this study was to evaluate the frequency, geographic distribution and nature of mutations in patients with CARD9 deficiency.

Investigation of Intertriginous Mycotic and Pseudomycotic (Erythrasma) Infections and Their Causative Agents with Emphasize on Clinical Presentations.

Background: Intertrigo is an erythematous inflammatory condition with multiple etiologies including fungi and bacteria. Intertrigo manifests in different clinical forms with various complaints. This study was conducted to evaluate the causative agents of intertriginous infections with emphasize on clinical presentations.

Aerobic Microbial Community of Insectary Population of Phlebotomus papatasi.

Background: Microbes particularly bacteria presenting in the gut of haematophagous insects may have an important role in the epidemiology of human infectious disease.

Methods: The microbial flora of gut and surrounding environmental of a laboratory strain of Phlebotomus papatasi, the main vector of Zoonotic Cutaneous Leishmaniasis (ZCL) in the old world, was investigated. Biochemical reactions and 16s rDNA sequencing of the isolated bacteria against 24 sugars and amino acids were used for bacteria species identification.

Multiple brain abscesses due to nocardia in an immunocompetent patient.

Nocardia cerebral abscesses are rare intracranial lesions. They account for only 1% to 2% of all brain abscesses. They are important in immunocompromised patients, but rarely occur in immunocompetent hosts.

First case of disseminated phaeohyphomycosis in an immunocompetent individual due to Alternaria malorum.

A 27-year-old Iranian, previously healthy male presented with sub-cutaneous necrotic lesions with a localized dermatosis affecting the anterior chest, neck and face. These lesions consisted of singular, well-defined verrucous plaques which gradually developed and disseminated over time. The dermatosis was followed by the development of necrotic swollen lesions localized on the hard palate.

A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-gamma.

Background: Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species.

Case Presentation: Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy.

Facial demodicosis.

A 24-year-old man presented with papulopustular, rosacea-like centro- facial lesions. Many Demodex mites were found in the affected area by microscopy of smears from pustules. This observation provides further evidence that demodicosis is a condition distinct from common rosacea.