Publications by authors named "Mohsen Ehsan"

Article Synopsis
  • Scientists are studying a disease called cystic echinococcosis (CE) to understand how it affects humans and why some people get it and others don't.
  • They looked at specific genes (HLA class II) in patients to see if there was a connection between these genes and different stages of the disease.
  • The study found that a certain gene (HLA-DRB1*03) was less common in sick people than in healthy ones, suggesting it might help protect against CE, but more research is needed to be sure.
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Article Synopsis
  • This study investigates the link between specific HLA alleles and the risk of acute lymphoblastic leukemia (ALL) in an Iranian population.
  • Using a case-control design, researchers compared 71 ALL patients to 71 healthy individuals and employed a specialized genetic testing technique for allele identification.
  • Results indicated that HLA-DRB1*04 is associated with a higher risk for ALL, while HLA-A*26, HLA-A*33, and HLA-DRB1*03 may provide protective benefits against the disease.
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Background: Acute lymphoblastic leukemia is the most prevailing pediatric hematologic malignancy, and various factors such as environmental exposures and genetic variation affect ALL susceptibility and patients outcome. According to genome-wide association studies, several single nucleotide polymorphisms (SNPs) in IKZF1 (rs4132601) and CDKN2A (rs3731249 and rs3731217) genes are associated with ALL susceptibility. Hereupon, this study aimed to discover the association between these SNPs and the risk of childhood ALL among a sample of the Iranian population.

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Objective: Acute lymphoblastic leukemia (ALL) is one of the most common cancers in children for which the exact pathogenesis is not yet known. Single-nucleotide variants (SNVs) in different DNA repair genes are reported to be associated with ALL risk. This study aimed to determine the association between XRCC1 (rs1799782) and NBN (rs1805794, rs709816) SNVs and childhood ALL risk in a sample of the Iranian population.

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Article Synopsis
  • The study investigates the effects of MST-312, a telomerase inhibitor derived from EGCG, on the human multiple myeloma cell line U-266, which is significant because telomerase is often active in cancer cells but inactive in most normal cells.
  • Researchers used various techniques to assess cell viability, apoptosis, and gene expression after treating U-266 cells with MST-312.
  • The results showed that MST-312 caused cell death and apoptosis by increasing the expression of the pro-apoptotic gene Bax while decreasing anti-apoptotic and proliferative gene levels, suggesting it could be an effective treatment strategy for multiple myeloma.
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