Application of Response Surface Methodology for Optimizing the Therapeutic Activity of ZnO Nanoparticles Biosynthesized from .

In this study, the biosynthesis of zinc oxide nanoparticles using (A/ZnO-NPs) is described. These particles have been characterized by UV-Vis spectrum analysis, X-ray powder diffraction, field emission scanning electron microscopy, and transmission electron microscopy. To use this biosynthesized nanoparticle as an antiproliferative and antimicrobial agent, the IC value against the breast cancer cell line and inhibition zone against were used to optimize the effect of two processing factors including dose of filtrate fungi cell and temperature.