Publications by authors named "Mohsen Arzanlou"
Background: Combination therapy including an aminoglycoside antibiotic and a cell-wall active agent is considered the most suitable option to treat invasive infections with methicillin-resistant Staphylococcus aureus (MRSA). Dual drug therapy enhances the effectiveness of treatment and reduces the risk of resistance development. This study aims to elucidate the phenotypic and molecular resistance to aminoglycosides and methicillin, and the molecular epidemiologic characteristics of S.
View Article and Find Full Text PDFBackground And Objectives: The global problem of urinary tract infections (UTIs) caused by antibiotic-resistant bacteria is due to limited treatment options. This study aimed to examine the prevalence, etiology, and management implications of causing UTI at Imam Hospital Ardabil, Iran.
Materials And Methods: 2340 samples of retrospective data on causing UTIs were collected at Imam Hospital in Ardabil, Iran, spanning from 2012 to 2022.
The carbapenem-resistant (CRE) pose a pressing public health concern. Here, we investigated the frequency of CRE bacteria, carbapenemase-encoding genes, and the molecular epidemiology of carbapenemase-resistant in wastewater resources and healthy carriers in Iran. Out of 617 bacteria, 24% were carbapenem-resistant.
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- Pseudomonas aeruginosa, a frequent cause of hospital infections, is showing increasing resistance to colistin, a key treatment option, complicating infection management.
- The study found a 9% rate of colistin resistance in clinical isolates, all of which were biofilm producers and exhibited specific genetic traits related to resistance mechanisms.
- The results emphasize the need for careful use of colistin to mitigate further resistance development among these bacterial strains in Ardabil hospitals.
Article Synopsis
- Beta-lactamase-producing Enterobacterales bacteria are causing increasingly severe infections, spreading outside hospitals, and posing a global health threat.
- A study in Ardabil, Iran, examined wastewater from livestock and poultry slaughterhouses, identifying 80 Enterobacterales isolates, primarily from Escherichia coli and Citrobacter spp.
- Among these, 18.7% were ESBL producers and 2.5% were AmpC producers, with all isolates being multidrug-resistant, raising concerns for zoonotic transmission to humans through contaminated food and the environment.
causes various toxigenic and invasive diseases in humans worldwide. This study examined the prevalence, virulence genes, and antibiotic resistance of isolates collected from 894 retail food samples in Ardabil, Iran. Staphylococcal cassette chromosome (SCC), , and multilocus sequence typing methods were employed to further investigate the molecular characteristics of methicillin-resistant (MRSA) isolates.
View Article and Find Full Text PDFAntimicrobial disinfectants have been extensively used to control hospital-acquired infections worldwide. Prolonged exposure to bacteria could promote resistance to antimicrobial disinfectants. This study evaluated the antimicrobial activity of four commonly used disinfectants; triclosan, chlorhexidine digluconate, benzalkonium chloride, and formaldehyde against Acinetobacter baumannii clinical isolates.
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- * Out of 146 isolates, 8.9% were ESBL-producers and 15.75% were AmpC-producers, with common resistant strains identified across all sections of the wastewater facility, particularly in effluent samples.
- * A significant number of these isolates showed multi-drug resistance, with the highest resistance rates against ampicillin, nalidixic acid, and cephalexin, raising concerns about antibiotic resistance in treated waste.
Background & Objective: causes various hospital- and community-acquired infections. This study aimed to investigate the phenotypic and genotypic characteristics of erythromycin and inducible clindamycin resistance, virulence gene profiles, and types of isolates collected from patients in Ardabil Province, Iran.
Methods: A total of 118 clinical isolates, including 50 (42.
Background And Objectives: Isoniazid and rifampin are the first -line drugs against Mycobacterium tuberculosis. Resistance to these important drugs is a serious threat to human public health. Therefore, this study aimed at molecular detection of resistance to these valuable drugs.
View Article and Find Full Text PDFHospital wastewater can contaminate the environment with antibiotic-resistant and virulent bacteria. We analyzed wastewater samples from four hospitals in Ardabil province, Iran for Enterococcus faecium and Enterococcus faecalis using culture and molecular methods. We also performed antimicrobial susceptibility testing and polymerase chain reaction testing for resistance and virulence genes.
View Article and Find Full Text PDFBackground And Aims: is a Gram-negative bacterium that colonized various organs. This bacterium is associated with different community-acquired and hospital-acquired infections. The present study aims to assess the capsular serotypes and frequency of virulence-associated genes in isolates from teaching hospitals in Ardabil, Iran.
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- The highest rates of resistance were found in isolates from clinical specimens (64.63%), while the lowest was from poultry wastewater (8.33%).
- Molecular analysis revealed significant mutations in the GyrA and topoisomerase IV subunits, and identified multiple plasmid-mediated quinolone resistance (PMQR) genes present in a subset of the resistant strains.
Background & Objective: Carbapenem-resistant is Gram-negative bacteria representing a worldwide public health problem. The present study aims to survey the phenotypic and genotypic characteristics of carbapenem-resistant isolates collected from hospitalized patients and outpatients in Ardabil province, Iran.
Methods: Two hundred samples were collected from the patients who had already been referred to the hospitals in Ardabil, Iran, from January to June 2017.
Fecal Carriage of Extended-Spectrum β-Lactamases and pAmpC Producing in an Iranian Community: Prevalence, Risk Factors, Molecular Epidemiology, and Antibiotic Resistance.
Microb Drug Resist
September 2022
Article Synopsis
- The study analyzed the prevalence of intestinal bacteria that produce extended-spectrum β-lactamases (ESBL) and plasmid-mediated AmpC β-lactamase (AmpC) in healthy children in Ardabil, Iran, finding that 21.5% were ESBL carriers, while lower rates had AmpC or both.
- The dominant bacterium identified was Escherichia coli, and most isolates were resistant to multiple antibiotics, including co-trimoxazole and tetracycline.
- The research highlighted a concerning level of multidrug-resistant bacteria in the gut of healthy children, with a statistical link to class sizes impacting ESBL-PE intestinal carriage rates.
Background: The objective of the current study is to evaluate the phenotypic and molecular characterization of ESBL/AmpC- and carbapenemase-producing K. pneumoniae isolates in Iran.
Methods: From October 2018 until the end of April 2020, different clinical samples were collected and K.
Enterococci are among the most common causes of nosocomial infections worldwide. Antimicrobial biocides are extensively used to control the growth of microorganisms on different surfaces. The purpose of this study was to determine the susceptibility of Enterococcus faecalis and Enterococcus faecium isolates collected in Iran to biocide agents, formaldehyde (FOR), benzalkonium chloride (BZC), triclosan (TRE), and chlorhexidine digluconate (CHDG).
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- Biocides are widely used to fight microorganisms but Pseudomonas aeruginosa is showing increasing resistance to them; this study assessed the effectiveness of four common biocides against these strains.
- A total of 76 clinical isolates were tested for their minimum inhibitory concentrations (MICs) against chlorhexidine digluconate, benzalkonium chloride, triclosan, and formaldehyde, with significant findings on resistance genes using PCR.
- The study found that chlorhexidine digluconate was the most effective biocide, but highlighted the need for ongoing monitoring due to the high prevalence of resistance genes among the P. aeruginosa strains tested.
Article Synopsis
- The study focused on the prevalence of high-level resistance to aminoglycosides and ampicillin among clinical isolates in Ardabil, Iran, due to the rising threat of nosocomial infections.
- Researchers collected 111 isolates from clinical specimens between 2013 and 2015 and used various methods, including PCR, to identify species and assess their resistance levels.
- Results showed a high prevalence of resistance, with 60.3% of isolates resistant to aminoglycosides and a significant 17.1% showing ampicillin resistance, indicating the need for routine resistance testing in clinical settings.
Background: This study aims to evaluate the efficiency of the TaqMan real-time PCR and serological methods in detecting Brucella spp. in clinical specimens that have been collected from suspected patients in Ardabil, Iran.
Methods: In this cross-sectional study, a total of 113 consecutive patients suspected of brucellosis who were referred to the three hospitals in Ardabil province were selected.
Background And Objectives: is an etiological agent of shigellosis. Antibiotic therapy has a critical role in decreasing serious complications of shigellosis. The present study aimed to determine the multi-drug resistance strains and to detect fluoroquinolone related mutations.
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- The study aimed to evaluate the antimicrobial resistance patterns of various serotypes, focusing on fluoroquinolone-resistant strains, from clinical samples in Iran.
- A thorough electronic search led to the selection of 46 relevant articles from over 13,000 studies published between 1983 and July 2019.
- Results indicated a 2.9% resistance to ciprofloxacin and 48.1% to nalidixic acid, with significant resistance also observed against other antibiotics, but ciprofloxacin and carbapenems remained effective against multi-drug resistant strains.
Objectives: High-level aminoglycoside, ampicillin and vancomycin resistance and virulence genes among enterococcal isolates collected from healthy middle-school children in Ardabil, Iran, during 2016 were investigated.
Methods: Totally, 305 faecal specimens were collected. Isolates underwent antimicrobial susceptibility testing, virulence gene detection and molecular typing.
Stone formation and catheter blockage are major complications of Proteus UTIs. In this study, we investigated the ability of allicin to inhibit P. mirabilis-induced struvite crystallization and catheter blockage using a synthetic bladder model.
View Article and Find Full Text PDFBackground: () is one of the most common causes of human diseases in young children. Macrolides are commonly antibiotics used for empirical treatment of community-acquired respiratory infections. The purpose of this study was to determine antibiotic resistance pattern as well as the relationship between macrolide resistance and the major mechanisms of resistance in pneumococci isolated from healthy children.
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