Publications by authors named "Mohmmad Saleem Dar"
Article Synopsis
- Pancreatic cancer is challenging to diagnose early and has a low survival rate, with current treatments providing limited benefits.
- Inhibiting Glycogen Synthase Kinase-3beta (GSK3β) is a promising therapeutic approach, as it's linked to cancer progression and drug resistance.
- MJ34 is identified as an effective GSK3β inhibitor that reduces tumor growth and promotes cell death in pancreatic cancer cells, showing potential as a drug candidate without significant toxicity.
Article Synopsis
- Scientists have found a new drug called MJ04 that could help with hair loss by blocking a specific part of a pathway in the body.
- This drug has shown great results in tests on mice, making their hair grow back quicker when applied directly to the skin.
- MJ04 is safe to use and works well, making it a good option for future studies in humans to help people with hair loss.
IGF1R is pursued as a therapeutic target because of its abnormal expression in various cancers. Recently, we reported the presence of a putative allosteric inhibitor binding pocket in IGF1R that could be exploited for developing novel anti-cancer agents. In this study, we examined the role of nine highly conserved residues surrounding this binding pocket, with the aim of screening compound libraries in order to develop small-molecule allosteric inhibitors of IGF1R.
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