Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.

Purpose: While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8 T cell, dynamics could allow early patient stratification and result in improved therapy efficacy and safety. In this study, we report the development of a nanobody-based immunotracer for non-invasive SPECT and PET imaging of human CD8 T-cell dynamics.

Treating low- and intermediate-risk acute promyelocytic leukemia with and without chemotherapy: A comparison in a tertiary care center.

Background: Acute promyelocytic leukemia (APL) comprises approximately 10% of acute myeloid leukemia (AML) cases.

Material And Methods: Both options of treatment (ATRA-ATO and ATRA-chemotherapy) were discussed with patients with low- and intermediate-risk APL, pros and cons explained in details, and treatment regimen selected after getting informed written consent.

Results: Total 71 patients were included in the study; among these patients, 3 were negative for both FISH for t (15,17) and RT-PCR for promyelocytic leukemia retinoic acid receptor alpha, and 36 patients with APL had white blood cell count at diagnosis >10 × 10/l.

Tumor-associated alterations in white matter connectivity have prognostic significance in MGMT-unmethylated glioblastoma.

Purpose: We investigated the prognostic significance of tumor-associated white matter (TA-WM) tracts in glioblastoma (GBM) using magnetic resonance-diffusion tensor imaging (MR-DTI). We hypothesized that (1) TA-WM tracts harbor microscopic disease not targeted through surgery or radiotherapy (RT), and (2) the greater the extent of TA-WM involvement, the worse the survival outcomes.

Methods: We studied a retrospective cohort of 76 GBM patients.

A comparative evaluation of bone regeneration using mesenchymal stem cells versus blood coagulum in sinus augmentation procedures.

Objective: The present study evaluated the quality and quantity of new bone formation in the maxillary sinus lift procedures and stability of implants in posterior atrophic maxilla.

Materials And Methods: This prospective randomized controlled split-mouth study included 20 patients (16 males and 4 females having a mean age of 36.7 years) having atrophic maxilla.

Chemical properties of emissions from solid residential fuels used for energy in the rural sector of the southern region of India.

In the present study, we have estimated the emission factors (EFs) of particulate matter (PM), organic and elemental carbon (OC and EC), oxide of sulfur and nitrogen, and water-soluble ionic species emitted from residential fuels (fuelwood, crop residue, dung cake) used in the rural sector of five states (Kerala, Karnataka, Andhra Pradesh, Telangana, Tamil Nadu) of the southern region of India. Average EFs of PM, OC, and EC from fuelwood (FW), crop residues (CR), and dung cakes (DC) from southern region of India are estimated as follows: PM: 6.35 ± 5.

A review on morphology, nanostructure, chemical composition, and number concentration of diesel particulate emissions.

Particulate matter (PM) emitted from compression ignition (CI) engines (diesel engines) has a detrimental effect on human health and the environment. The physical and chemical characteristics of PM emitted from CI-engines are influenced by engine operating conditions and fuel properties. The morphology, nanostructure, and chemical composition of PM affect its toxicity and interaction with the environment.

Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder.

Deep brain stimulation (DBS) promises to treat an increasing number of neurological and psychiatric disorders. DBS outcome is directly a factor of optimal targeting of the relevant brain structures. Computational models can help to interpret a patient's outcome by predicting the volume of tissue activated (VTA) around DBS electrode contacts.

For a critical appraisal of artificial intelligence in healthcare: The problem of bias in mHealth.

Rationale, Aims And Objectives: Artificial intelligence and big data are more and more used in medicine, either in prevention, diagnosis or treatment, and are clearly modifying the way medicine is thought and practiced. Some authors argue that the use of artificial intelligence techniques to analyze big data would even constitute a scientific revolution, in medicine as much as in other scientific disciplines. Moreover, artificial intelligence techniques, coupled with mobile health technologies, could furnish a personalized medicine, adapted to the individuality of each patient.

Source Apportionment of PM Over Three Tropical Urban Atmospheres at Indo-Gangetic Plain of India: An Approach Using Different Receptor Models.

The present work is the ensuing part of the study on spatial and temporal variations in chemical characteristics of PM (particulate matter with aerodynamic diameter ≤ 10 μm) over Indo Gangetic Plain (IGP) of India. It focuses on the apportionment of PM sources with the application of different receptor models, i.e.

Stable carbon and nitrogen isotopic composition of PM over Indo-Gangetic Plains (IGP), adjoining regions and Indo-Himalayan Range (IHR) during a winter 2014 campaign.

For source identification, a field campaign involving simultaneous sampling of particulate matter (PM) was conducted at eight sampling sites in the Indian mainland during winter 2014. The sampling sites include Delhi (upper IGP), Lucknow (middle IGP), and Kolkata (lower IGP) in the Indo-Gangetic Plains (IGP); Mohal-Kullu and Darjeeling in the Indo-Himalayan Range (IHR). In addition, Ajmer, located upwind of the IGP in NW-India and Giridih and Bhubaneswar, in the downwind to the IGP has also been chosen.

Effect of compression ratio, nozzle opening pressure, engine load, and butanol addition on nanoparticle emissions from a non-road diesel engine.

Currently, diesel engines are more preferred over gasoline engines due to their higher torque output and fuel economy. However, diesel engines confront major challenge of meeting the future stringent emission norms (especially soot particle emissions) while maintaining the same fuel economy. In this study, nanosize range soot particle emission characteristics of a stationary (non-road) diesel engine have been experimentally investigated.

Chemical characteristics and source apportionment of PM using PCA/APCS, UNMIX, and PMF at an urban site of Delhi, India.

The present study investigated the comprehensive chemical composition [organic carbon (OC), elemental carbon (EC), water-soluble inorganic ionic components (WSICs), and major & trace elements] of particulate matter (PM) and scrutinized their emission sources for urban region of Delhi. The 135 PM samples were collected from January 2013 to December 2014 and analyzed for chemical constituents for source apportionment study. The average concentration of PM was recorded as 121.

Inter-annual Variation of Ambient Ammonia and Related Trace Gases in Delhi, India.

In this study, ambient NH, NO, NO, CO and SO were measured continuously from February, 2008, to December, 2016. The annual average mixing ratios (mole/mole) of NH, NO, NO, CO and SO were 17.8 ± 3.

Seasonal characteristics of water-soluble inorganic ions and carbonaceous aerosols in total suspended particulate matter at a rural semi-arid site, Kadapa (India).

To better understand the sources as well as characterization of regional aerosols at a rural semi-arid region Kadapa (India), size-resolved composition of atmospheric particulate matter (PM) mass concentrations was sampled and analysed. This was carried out by using the Anderson low-pressure impactor for a period of 2 years during March 2013-February 2015. Also, the variations of organic carbon (OC), elemental carbon (EC) and water-soluble inorganic ion components (WSICs) present in total suspended particulate matter (TSPM) were studied over the measurement site.

Source Apportionment of PM2.5 in Delhi, India Using PMF Model.

Chemical characterization of PM2.5 [organic carbon, elemental carbon, water soluble inorganic ionic components, and major and trace elements] was carried out for a source apportionment study of PM2.5 at an urban site of Delhi, India from January, 2013, to December, 2014.

Variation of Stable Carbon and Nitrogen Isotopic Composition of PM10 at Urban Sites of Indo Gangetic Plain (IGP) of India.

This paper presents the variation of elemental concentrations of total carbon (TC), total nitrogen (TN) and isotopic ratios of δ13C and δ15N along with δ13OC and OC of PM10 mass over Delhi, Varanasi and Kolkata of the Indo Gangetic Plain (IGP), India. For Delhi, the average concentrations of TC and TN of PM10 were 53.0±33.

Assessing speech dysfunction using BOLD and acoustic analysis in parkinsonism.

Introduction: Speech dysfunction is often associated with parkinsonism (Parkinson's disease (PD), Multiple System Atrophy (MSA), and Progressive Supranuclear Palsy (PSP)), along with characteristic motor features. Any or all of the following i.e.

Cytotoxic evaluation of semisynthetic ester and amide derivatives of oleanolic acid.

Although a number of chemicals have been isolated from Lantana camara, only a few have been evaluated for their biological significance. As part of our drug discovery program for cytotoxic agents from Indian medicinal plants, roots of L. camara L.

Cytotoxic agents from Terminalia arjuna.

Although a number of chemicals have been isolated from Terminalia arjuna, only a few have been evaluated for their biological significance. As a part of our drug discovery programme for cytotoxic agents from Indian medicinal plants, four novel cytotoxic agents arjunic acid (1), arjungenin (2), arjunetin (3) and arjunoglucoside I (4) were isolated from the bark of T. ARJUNA.