Alpha-Lipoic acid alleviates imidacloprid-induced neuro-behavioral deficits in rats Nrf2/HO-1 pathway.

Imidacloprid (IMI), a widely used pesticide in agriculture and a potential food contaminant, poses significant health concerns. This study sought to comprehensively evaluate its neurotoxic effects while investigating the potential protective role of alpha-lipoic acid (ALA), a naturally occurring dietary antioxidant renowned for its capacity to combat oxidative stress, support cardiovascular health, and maintain optimal nerve function. In this study, 28 rats were divided evenly into four groups and administered oral treatments of corn oil, IMI, IMI + ALA, and ALA, respectively.

Theory for size segregation in flowing granular mixtures based on computation of forces on a single large particle.

We measure the upward force acting on a single, unconstrained, large particle in a granular medium of small particles flowing over inclined plane using discrete element method (DEM) simulation. Based on the computed force, we obtain an expression for the flux of large particles in a binary mixture of large and small particles and predict the equilibrium concentration profile and the velocity profile of the flowing layer. The theoretical predictions are in very good agreement with the DEM simulation results for a wide range of concentrations of large particles and inclination angles.