Publications by authors named "Mohini Bryant-Ekstrand"
Article Synopsis
- * A study of veterans revealed significant reductions in heart rate variability (HRV) during NREM sleep for RBD+NT participants, indicating greater autonomic dysfunction.
- * These findings suggest that HRV during sleep could serve as an early biomarker for diagnosing and understanding neurodegenerative conditions in individuals with RBD+NT.
Sleep-wake disturbances frequently present in Veterans with mild traumatic brain injury (mTBI). These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to improve sleep following mTBI are limited and studies in Veterans are even more scarce.
View Article and Find Full Text PDFArticle Synopsis
- RBD is a sleep disorder that can lead to serious brain diseases like Parkinson's, especially in people with past brain injuries or stress.
- People with both RBD and past trauma had their RBD symptoms start earlier and were more severe than those with just RBD.
- The study found that those with both RBD and trauma experienced worse mental and physical health, suggesting a possible link to worsening brain problems over time.
Background And Objectives: Although orthostatic hypotension (OH) can be an early feature of autonomic dysfunction in isolated REM sleep behavior disorder (iRBD), no large-scale studies have examined the frequency of OH in iRBD. In this study, we prospectively evaluated the frequency of OH in a large multicenter iRBD cohort.
Methods: Participants 18 years or older with video polysomnogram-confirmed iRBD were enrolled through the North American Prodromal Synucleinopathy consortium.
New Findings: What is the central question of this study? Does the hyperbaric, hypercapnic, acidotic, hypoxic stress of apnoea diving lead to greater pulmonary vasoreactivity and increased right heart work in apnoea divers? What is the main finding and its importance? Compared with sex- and age-matched control subjects, divers experienced significantly less change in total pulmonary resistance in response to short-duration isocapnic hypoxia. With oral sildenafil (50 mg), there were no differences in total pulmonary resistance between groups, suggesting that divers can maintain normal pulmonary artery tone in hypoxic conditions. Blunted hypoxic pulmonary vasoconstriction might be beneficial during apnoea diving.
View Article and Find Full Text PDFObjectives: During apnea diving, a patent foramen ovale may function as a pressure relief valve under conditions of high pulmonary pressure, preserving left-ventricular output. Patent foramen ovale prevalence in apneic divers has not been previously reported. We aimed to determine the prevalence of patent foramen ovale in apneic divers compared to non-divers.
View Article and Find Full Text PDF