Publications by authors named "Mohini Aiyengar Tupurani"
Cytokines are multifunctional glycoproteins that play a vital role in the tumor microenvironment and progression of breast cancer. Genetic polymorphisms may influence the immune responses restrained by pro- and anti-inflammatory cytokine expression in tumors. Hence, the present study evaluated the contribution of Interleukin (IL) 6 (rs1800797, rs1800796, and rs1800795) and IL18 (rs1946518, rs187238, and rs549908) genotypes and their haplotypes to the risk, progression of breast cancer in South Indian population.
View Article and Find Full Text PDFIntroduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.
View Article and Find Full Text PDFCollagenase-1 (-1607 1G/2G), Gelatinase-A (-1306 C/T), Stromelysin-1 (-1171 5A/6A) functional promoter polymorphisms in risk prediction of type 2 diabetic nephropathy.
Gene
October 2018
Type 2 Diabetic Nephropathy (DN) is a common multifactorial disorder. Degradation of glomerular basement membrane (GBM) by matrix metalloproteases (MMPs) is a key event in the progression of renal disease. A functional polymorphism at position -1607 1G/2G, -1306 C/T and -1171 5A/6A has been shown to alter the transcriptional activity of MMP-1, MMP-2, and MMP-3 respectively, and also associated with several diseases contributing to inter-individual differences in susceptibility to type 2 DN.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers genotyped specific SNPs in 300 breast cancer patients and 300 healthy controls, utilizing various statistical software for analysis to find significant associations between certain alleles and increased breast cancer susceptibility.
- * Findings indicated that specific MMP polymorphisms are associated with clinical characteristics like hormone receptor status and metastasis, suggesting that these genetic variations collectively increase breast cancer risk and may influence patient survival.
Article Synopsis
- * The study analyzes polymorphisms in CASP8 and CASP3 genes among 300 CAD patients and 300 healthy controls, using genetic testing methods to identify variations linked to disease risk.
- * Findings indicate that certain genotypes of CASP8 and CASP3 are associated with an increased risk of CAD, suggesting these polymorphisms could serve as genetic markers for the disease.