Comparative Evaluation of Compressive and Diametral Tensile Strength in Die Stone Reinforced With Different Types of Nanoparticles: An In Vitro Study.

Aim: To investigate the effect of different types of nanoparticles on the compressive strength (CS) and diametral tensile strength (DTS) of type IV dental stones.

Materials And Methods: A total of 100 specimens were made from the mould for all five groups. Four commercially available nanoparticles (aluminium oxide (AlO), silicon dioxide (SiO), zinc oxide (ZnO), and zirconium oxide (ZrO)) were used in this study in a concentration of 10%.

A Comparative Evaluation of Flexural and Impact Strength of Polymethyl Methacrylate (PMMA) Reinforced With Graphene and Multi-Walled Carbon Nanotubes: An In Vitro Study.

Background and objective Low flexural strength (FS) and impact strength (IS) are major drawbacks in removable prostheses made from polymethyl methacrylate (PMMA). Attempts to enhance the strength and longevity of these prostheses have been of keen interest among researchers. Nanofillers are new and advanced reinforcements that can chemically modify PMMA.

DDX3-mediated miR-34 expression inhibits autophagy and HBV replication in hepatic cells.

HBV entry to the host cells and its successful infection depends on its ability to modulate the host restriction factors. DEAD box RNA helicase, DDX3, is shown to inhibit HBV replication. However, the exact mechanism of inhibition still remains unclear.

Exosome-encapsulated ncRNAs: Emerging yin and yang of tumor hallmarks.

Tumorigenesis is a multifaceted process, where multiple physiological traits serving as cancer's distinctive characteristics are acquired. "Hallmarks of cancer" is a set of cognitive abilities acquired by human cells that are pivotal to their tumor-forming potential. With limited or no protein-coding ability, non-coding RNAs (ncRNAs) interact with their target molecules and yield significant regulatory effects on several cell cycle processes.

Immunotherapy With 5, 15-DPP Mediates Macrophage M1 Polarization and Modulates Subsequent Infectivity in rBCG30 Immunized Mice.

Tuberculosis (TB) is a significant and continuing problem worldwide, with a death toll of around 1.5 million human lives annually. BCG, the only vaccine against TB, offers a varied degree of protection among human subjects in different regions and races of the world.

Corrigendum: Selective Targeting of 4SO--Acetyl-Galactosamine Functionalized Protein Loaded Chitosan Nanoparticle to Macrophages: Correlation With Activation of Immune System.

[This corrects the article DOI: 10.3389/fmicb.2018.

Hydroxyapatite Nanoparticles Fortified Xanthan Gum-Chitosan Based Polyelectrolyte Complex Scaffolds for Supporting the Osteo-Friendly Environment.

Nanoparticle-reinforced polymer-based scaffolding matrices as artificial bone-implant materials are potential suitors for bone regenerative medicine as they simulate the native bone. In the present work, a series of bioinspired, osteoconductive tricomposite scaffolds made up of nano-hydroxyapatite (NHA) embedded xanthan gum-chitosan (XAN-CHI) polyelectrolyte complex (PEC) are explored for their bone-regeneration potential. The Fourier transform infrared spectroscopy studies confirmed complex formation between XAN and CHI and showed strong interactions between the NHA and PEC matrix.

Corrigendum: -Specific Promiscuous Membrane Protein Tubulin Folding Cofactor D Divulges Th/Th Polarization in the Host via ERK-1/2 and p38 MAPK Signaling Cascade.

[This corrects the article DOI: 10.3389/fimmu.2020.

-Specific Promiscuous Membrane Protein Tubulin Folding Cofactor D Divulges Th/Th Polarization in the Host via ERK1/2 and p38 MAPK Signaling Cascade.

Visceral leishmaniasis (VL)-related mortality and morbidity imposes a great deal of health concern across the globe. The existing anti-leishmanial drug regimen generally fails to eliminate newly emerging resistant isolates of this dreadful parasite. In such circumstances, the development of a prophylactic strategy to impart protection against the disease is likely to take center stage.

Bio-mediated synthesis of 5-FU based nanoparticles employing orange fruit juice: a novel drug delivery system to treat skin fibrosarcoma in model animals.

Nano-sized drug delivery systems (NDDS) have been widely exploited to achieve targeted delivery of pharmaco-materials. Traditional pharmaceutical approaches, implied in the synthesis of nano-formulations, are obscure owing to the incompatible physico-chemical properties of the core drug as well as some other factors crucial in development of NDDS. Infact, most of the existing methods used in development of NDDS rely on usage of additives or excipients, a special class of chemicals.

Selective Targeting of 4SO--Acetyl-Galactosamine Functionalized Protein Loaded Chitosan Nanoparticle to Macrophages: Correlation With Activation of Immune System.

In the present study, we investigated potential of chitosan-based nanoparticles (CNPs) to deliver loaded therapeutic molecules to pathogen harboring macrophages. We fabricated stable CNPs employing ionic cross-linking method and evaluated their potential to target RAW 264.7 cells.

Pattern of Cancers Treated with Radiotherapy in Uduth Sokoto: A New Center Experience.

Background: Cancer is a leading public health problem worldwide. In many developing countries, cancer tends to present in predominantly advanced stages, to a certain extent due to lack of comprehensive screening and poor access to efficient management. This study was carried out to describe the pattern of cancers managed in the Department of Radiotherapy and Oncology in Usmanu Danfodiyo University Teaching Hospital Sokoto, North-western Nigeria.

Amyloid form of ovalbumin evokes native antigen-specific immune response in the host: prospective immuno-prophylactic potential.

Amyloids are highly organized protein aggregates that arise from inappropriately folded versions of proteins or polypeptides under both physiological as well as simulated ambiences. Once thought to be irreversible assemblies, amyloids have begun to expose their more dynamic and reversible attributes depending upon the intrinsic properties of the precursor protein/peptide and experimental conditions such as temperature, pressure, structural modifications in proteins, or presence of chemicals in the reaction mixture. It has been repeatedly proposed that amyloids undergo transformation to the bioactive peptide/protein forms under specific conditions.