Antibiotic Biosynthesis Pathways from Endophytic SUK 48 through Metabolomics and Genomics Approaches.

sp. has been known to be a major antibiotic producer since the 1940s. As the number of cases related to resistance pathogens infection increases yearly, discovering the biosynthesis pathways of antibiotic has become important.

Metabolite profiling of endophytic spp. and its antiplasmodial potential.

Background: Antiplasmodial drug discovery is significant especially from natural sources such as plant bacteria. This research aimed to determine antiplasmodial metabolites of spp. against 3D7 by using a metabolomics approach.

Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach.

Natural products continue to play an important role as a source of biologically active substances for the development of new drug. , Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria.

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic SUK10.

Endophytic strains are potential sources for novel bioactive molecules. In this study, the diketopiperazine gancidin W (GW) was isolated from the endophytic actinobacterial genus , SUK10, obtained from the bark of tree, and it was tested in vivo against PZZ1/100. GW exhibited an inhibition rate of nearly 80% at 6.

In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10.

Endophytic bacteria, such as Streptomyces, have the potential to act as a source for novel bioactive molecules with medicinal properties. The present study was aimed at assessing the antimalarial activity of crude extract isolated from various strains of actinobacteria living endophytically in some Malaysian medicinal plants. Using the four day suppression test method on male ICR strain mice, compounds produced from three strains of Streptomyces (SUK8, SUK10, and SUK27) were tested in vivo against Plasmodium berghei PZZ1/100 in an antimalarial screen using crude extracts at four different concentrations.