Oral Hygiene Practices and the Awareness of Perio-Systemic Interrelationship Among the Population of Ranchi City: A Hospital-Based Study.

Background: The concept of the pathogenesis and etiology of periodontal disease, with their infectious and chronic natures, usually facilitates acknowledging the possibility of these infections influencing events elsewhere in the body. Concurrent awareness and recognition of the interaction between systemic and oral diseases are one of the enormous advances that require a periodontist to not only strictly direct their knowledge toward prevention and treatment but also spread awareness about the same among the unknown. Thus, the primary goal of our study was to assess public awareness of periodontal and systemic interrelationships with oral hygiene practices in Ranchi, Jharkhand.

Acute variceal bleeding portends poor outcomes in patients with acute-on-chronic liver failure: a propensity score matched study from the APASL ACLF Research Consortium (AARC).

Background And Aims: Limited data exist regarding outcomes of acute variceal bleeding (AVB) in patients with acute-on-chronic liver failure (ACLF), especially in those with hepatic failure. We evaluated the outcomes of AVB in patients with ACLF in a multinational cohort of APASL ACLF Research Consortium (AARC).

Methods: Prospectively maintained data from AARC database on patients with ACLF who developed AVB (ACLF-AVB) was analysed.

Use of thopaz in patients of empyema thoracis undergoing decortication.

Introduction: The management of empyema thoracis has evolved over the years. After all lung surgeries chest drain is required, however they suffer from inter observer variability and impair mobility of the patient. However, the newer digital thoracic drain system are portable and have alarms for various situations, furthermore they eliminate inter-observer variability.

Impact of metabolic risk factors on the severity and outcome of patients with alcohol-associated acute-on-chronic liver failure.

Background: Metabolic risk factors may impact the severity and outcome of alcoholic liver disease. The present study evaluated this effect in patients with alcohol-associated acute-on-chronic liver failure (ACLF).

Methodology: One thousand two hundred and sixteen prospectively enrolled patients with ACLF (males 98%, mean age 42.

Association of Gene Mutation With Infection in Gastric Cancer Patients and Its Correlation With Clinicopathological and Environmental Factors.

Background: Gastric cancer is also a leading cancer in Bangladesh like that of the global incidences. It is speculated that environmental, bacterial infection and molecular factors might have been carrying the key role of rising trend of the disease. This study was aimed to investigate the association of mutated gene with of () infection, clinicopathological and some environmental factors of the gastric cancer patients.

Polysomnographic correlates of inflammatory complement components in young healthy males.

A growing body of evidence has delineated the predominant role of humoral mediators of inflammation in linking sleep with immunity. Nonetheless, characterization of the relationship between complement components with inflammatory functions and objective sleep measures has not been performed. In this study we investigated the relationships between objective measures of sleep and complement components with inflammatory functions.

Multiple Plasmodium vivax proteins of Pv-fam-a family interact with human erythrocyte receptor Band 3 and have a role in red cell invasion.

Elucidation of molecular mechanisms of receptor-ligand biology during host-parasite interaction helps in developing therapeutic targets. Several Pv-fam-a family proteins of Plasmodium vivax bind to host erythrocytes but their erythrocyte receptors remains to be explored. Here, we show that three merozoite proteins (PvTRAg36, PvATRAg74, and PvTRAg38) of this family interact with Band 3 on human erythrocytes through its three exofacial loops (loop 1, loop 3, and loop 6).

Receptor specific binding regions of Plasmodium vivax tryptophan rich antigens and parasite growth inhibition activity of PvTRAg35.2.

Plasmodium tryptophan rich proteins play important role in host-parasite interaction. Earlier, we have described that one of the merozoite expressed Plasmodium vivax tryptophan-rich antigen PvTRAg35.2 binds to the host erythrocytes, have conserved sequences in parasite population, and generates humoral as well as cellular immune responses in humans during this parasitic infection.

Host-parasite interaction: multiple sites in the Plasmodium vivax tryptophan-rich antigen PvTRAg38 interact with the erythrocyte receptor band 3.

Tryptophan-rich antigens of malarial parasites interact with host molecules and play an important role in parasite survival. Merozoite expressed Plasmodium vivax tryptophan-rich antigen PvTRAg38 binds to human erythrocytes and facilitates parasite growth in a heterlologous Plasmodium falciparum culture system. Recently, we identified band 3 in human erythrocytes as one of its receptors, although the receptor-ligand binding mechanisms remain unknown.

Recognition of Human Erythrocyte Receptors by the Tryptophan-Rich Antigens of Monkey Malaria Parasite Plasmodium knowlesi.

Background: The monkey malaria parasite Plasmodium knowlesi also infect humans. There is a lack of information on the molecular mechanisms that take place between this simian parasite and its heterologous human host erythrocytes leading to this zoonotic disease. Therefore, we investigated here the binding ability of P.

Interaction of Plasmodium vivax Tryptophan-rich Antigen PvTRAg38 with Band 3 on Human Erythrocyte Surface Facilitates Parasite Growth.

Plasmodium tryptophan-rich proteins are involved in host-parasite interaction and thus potential drug/vaccine targets. Recently, we have described several P. vivax tryptophan-rich antigens (PvTRAgs), including merozoite expressed PvTRAg38, from this noncultivable human malaria parasite.

Host-parasite interaction: selective Pv-fam-a family proteins of Plasmodium vivax bind to a restricted number of human erythrocyte receptors.

Background: Plasmodium vivax synthesizes the largest number of 36 tryptophan-rich proteins belonging to the Pv-fam-a family. These parasite proteins need to be characterized for their biological function because tryptophan-rich proteins from other Plasmodium species have been proposed as vaccine candidates.

Methods: Recombinant P.

Protective effects of Punica granatum in experimentally-induced gastric ulcers.

In the present investigation standardized aqueous methanolic extract of Punica (AMP) was used for its possible ulcer protective activity in wistar rats against different experimental models. Preliminary phytochemical screening of AMP reveals the presence of saponin, tannins, and flavonoids, which may be responsible for its activity. HPTLC finger prints of AMP showed the presence of 12 spots at different (retention factor) rf values.

Gallic acid esters from the stem bark of Mimusops elengi L.

Phytochemical investigation of the ethanolic extract of the stem bark of Mimusops elengi L. (Sapotaceae) led to the isolation of new gallic acid esters, characterised as phenyl propanoxyl gallate (1), beta-D-glucopyranosyl (6'-->1'')-beta-D-glucopyranosyl-4''-(4''-ethylphenyl) gallate (2), 2'-(1'''-geranyloxy)-beta-D-glucopyranosyl (6'-->1'')-beta-D-glucopyranosyl-4''-phenoxy gallate (3), beta-D-glucopyranosyl (6'-->1'')-beta-D-glucopyranosyl 3,4,5-trihydroxy benzoate (4), beta-D-glucopyranosyl-(6'-->1'')-beta-D-glucopyranosyl-4''-(4'''-n-butylphenyl) 3,4,5-trihydroxy benzoate (5), beta-D-glucopyranosyl(6'-->1'')-beta-D-rhamnosyl 3,4,5-trihydroxy benzoate (6) and beta-D-(2'-phenyl glucopyranosyl)-(6'-->1'')-(2'', 4''-diphenylrhamnopyranosyl)-3,4,5-trihydroxylbenzoate (7), along with the known compounds: farnon-3-one, stigmasta-5-en-3-beta-ol, olean-18-en-2-one-3-ol, lup-20(29)-en-3beta-ol and stigmasta-5-en-3beta-D-glucopyranoside. Their structures were elucidated on the basis of spectroscopic analyses and chemical reactions.

New coumarin glycosides from Rhododendron lepidotum.

Two new coumarin glycosides, named Rhodonin (1) and Rhodonetin (2) were isolated from the aerial parts of Rhododendron lepidotum.